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References (82)
-
Lactic acid accumulation as a cause of brain edema and cerebral necrosis resulting from oxygen deprivation -
Auer Auer, Kalimo Kalimo, Olsson Olsson, Siesjö Siesjö (1985)
The temporal evolution of hypoglycemic brain damage: I. Light and electron microscopic findings in the rat cerebral cortexActa Neuropathol (Berl), 67
-
K. Norberg, B. Siesjou (1976)
OXIDATIVE METABOLISM OF THE CEREBRAL CORTEX OF THE RAT IN SEVERE INSULIN‐INDUCED HYPOGLYCAEMIAJournal of Neurochemistry, 26
-
J. Drejer, H. Benveniste, N. Diemer, A. Schousboe (1985)
Cellular Origin of Ischemia‐Induced Glutamate Release from Brain Tissue In Vivo and In VitroJournal of Neurochemistry, 45
-
James Miller, R. Myers (1972)
Neuropathology of systemic circulatory arrest in adult monkeysNeurology, 22
-
J. Brierley, Meldrum Bs, A. Brown (1973)
The threshold and neuropathology of cerebral "anoxic-ischemic" cell change.Archives of neurology, 29 6
-
C. Agardh, H. Kalimo, Y. Olsson, B. Siesjö (1981)
Hypoglycemic Brain Injury: Metabolic and Structural Findings in Rat Cerebellar Cortex during Profound Insulin-Induced Hypoglycemia and in the Recovery Period following Glucose AdministrationJournal of Cerebral Blood Flow & Metabolism, 1
-
Auer Auer (1986)
Hypoglycemic brain damageStroke, 17
-
B. Mersey, M. Mccully (1978)
Monitoring of the course of fixation of plant cellsJournal of Microscopy, 114
-
Hillered Hillered, Smith Smith, Siesjö Siesjö (1985)
Lactic acidosis and recovery of mitochondrial function following forebrain ischemia in the ratJ Cereb Blood Flow Metab, 5
-
T. Wieloch, B. Engelsen, E. Westerberg, R. Auer (1985)
Lesions of the glutamatergic cortico-striatal projections in the rat ameliorate hypoglycemic brain damage in the striatumNeuroscience Letters, 58
-
(1988)
Auer R N . The nature and timing of excitotoxic neuronal necrosis in thc cerebrai cortex, hippocampus and thalamus due to flurothyl-induced status epilepticus -
R. Hart, D. Sherman, C. Tegeler (1985)
Predicting outcome from hypoxic-ischemic coma.JAMA, 254 9
-
T. Duffy, D. Howse, F. Plum (1975)
CEREBRAL ENERGY METABOLISM DURING EXPERIMENTAL STATUS EPILEPTICUS 1Journal of Neurochemistry, 24
-
(1987)
Mitochondrial my-1981 -
W. Pulsinelli, J. Brierley, F. Plum (1982)
Temporal profile of neuronal damage in a model of transient forebrain ischemiaAnnals of Neurology, 11
-
B. Siesjö (1988)
Historical OverviewAnnals of the New York Academy of Sciences, 522
-
Auer Auer, Kalimo Kalimo, Olsson Olsson, Siesjö Siesjö (1985)
The temporal evolution of hypoglycemic brain damage: II. Light and electron:, microscopic findings in the rat hippocampusActa Neuropaths (Berl), 67
-
D. Monaghan, D. Yao, H. Olverman, J. Watkins, C. Cotman (1984)
Autoradiography of d-2-[3H]amino-5-phosphonopentanoate binding sites in rat brainNeuroscience Letters, 52
-
W. Pulsinelli, D. Levy, T. Duffy (1982)
Regional cerebral blood flow and glucose metabolism following transient forebrain ischemiaAnnals of Neurology, 11
-
K. Hossmann, P. Kleihues (1973)
Reversibility of ischemic brain damage.Archives of neurology, 29 6
-
T. Wieloch (1985)
Hypoglycemia-induced neuronal damage prevented by an N-methyl-D-aspartate antagonist.Science, 230 4726
-
Brian Meidrum, James Brierlev (1973)
Prolonged epileptic seizures in primates. Ischemic cell change and its relation to ictal physiological events.Archives of neurology, 28 1
-
(1985)
The temporal cvolut ~ on o f hypoglycemic brain damage : 111 . Light and electron niicrcscopic findings in the rat caudoputamen -
B. Siesjö (1988)
Hypoglycemia, brain metabolism, and brain damage.Diabetes/metabolism reviews, 4 2
-
Smith Smith, Kalimo Kalimo, Warner Warner, Siesjö Siesjö (1988)
Morphological lesions in the brain preceding the development of postischemic seizuresActa Neuropathol (Berl), 76
-
M. Sandberg, S. Butcher, H. Hagberg (1986)
Extracellular Overflow of Neuroactive Amino Acids During Severe Insulin‐Induced Hypoglycemia: In Vivo Dialysis of the Rat HippocampusJournal of Neurochemistry, 47
-
Hossmann Hossmann, Lechtape‐Grüter Lechtape‐Grüter, Hossmann Hossmann (1973)
The role of cerebral blood flow for the recovery of the brain after prolonged ischemiaZeits Neurol, 204
-
J. Olney, T. DeGubareff, R. Sloviter (1983)
“Epileptic” brain damage in rats induced by sustained electrical stimulation of the perforant path. II. Ultrastructural analysis of acute hippocampal pathologyBrain Research Bulletin, 10
-
B. Ljunggren, K. Norberg, B. Siesjö (1974)
Influence of tissue acidosis upon restitution of brain energy metabolism following total ischemia.Brain research, 77 2
-
Kågström Kågström, Smith Smith, Siesjö Siesjö (1983)
Local cerebral blood flow in the recovery period following complete cerebral ischemia in the ratJ Cereb Blood Flow Mctab, 3
-
A. Hakim (1984)
The induction and reversibility of cerebral acidosis in thiamine deficiencyAnnals of Neurology, 16
-
T. Griffiths, M. Evans, B. Meldrum (1983)
Intracellular calcium accumulation in rat hippocampus during seizures induced by bicuculline orl-allylglycineNeuroscience, 10
-
MD Hakim, PhD Pappius (1983)
Sequence of metabolic, clinical, and histological events in experimental thiamine deficiencyAnnals of Neurology, 13
-
W. Pulsinelli, D. Levy, B. Sigsbee, P. Scherer, F. Plum (1983)
Increased damage after ischemic stroke in patients with hyperglycemia with or without established diabetes mellitus.The American journal of medicine, 74 4
-
G. Nevander, M. Ingvar, R. Auer, B. Siesjö (1985)
Status epilepticus in well–oxygenated rats causes neuronal necrosisAnnals of Neurology, 18
-
F. Fonnum (1984)
Glutamate: A Neurotransmitter in Mammalian BrainJournal of Neurochemistry, 42
-
E. Kågström, Maj-lis Smith, B. Siesjö (1983)
Local Cerebral Blood Flow in the Recovery Period following Complete Cerebral Ischemia in the RatJournal of Cerebral Blood Flow & Metabolism, 3
-
Auer Auer, Kalimo Kalimo, Olsson Olsson, Wieloch Wieloch (1985)
The dentate gyrus in hypoglycemia. Pathology implicating excitotoxin‐mediated neuronal necrosisActa Neuropathol (Bed), 67
-
T. Koide, T. Wieloch, B. Siesjö (1986)
Circulating Catecholamines Modulate Ischemic Brain DamageJournal of Cerebral Blood Flow & Metabolism, 6
-
(1984)
The density and distribution of ischemic brain injury in the rat after 2-10 minutes of fore-brain ischemia -
A. Lehmann, H. Hagberg, I. Jacobson, A. Hamberger (1985)
Effects of status epilepticus on extracellular amino acids in the hippocampusBrain Research, 359
-
R. Auer, Y. Olsson, B. Siesjö (1984)
Hypoglycemic Brain Injury in the Rat: Correlation of Density of Brain Damage with the EEG Isoelectric Time: A Quantitative StudyDiabetes, 33
-
Kiessling Kiessling, Kleihues Kleihues (1981)
Regional protein synthesis in the rat brain during bicuculline‐induced epileptic seizuresActa Neuropathol (Berl), 55
-
J. Greenamyre, James Olson, J. Penney, Anne Young (1985)
Autoradiographic characterization of N-methyl-D-aspartate-, quisqualate- and kainate-sensitive glutamate binding sites.The Journal of pharmacology and experimental therapeutics, 233 1
-
Söderfeldt Söderfeldt, Kalimo Kalimo, Olsson Olsson, Siesjö Siesjö (1981)
Pathogenesis of brain lesions caused by experimental epilepsy. Light and electron microscopic changes in the rat cerebral cortex following bicuculline‐induced status epilepticusActa Neuropathol (Berl), 54
-
S. Rothman, J. Olney (1986)
Glutamate and the pathophysiology of hypoxic–ischemic brain damageAnnals of Neurology, 19
-
Siesjö Siesjö (1988)
Calcium ischemia, and death of brain cellsAnn NY Acad Sci, 522
-
Kirino Kirino, Tamura Tamura, Sano Sano (1984)
Delayed neuronal death in the rat hippocampus following transient forebrain ischemiaActa Neuropathol (Berl), 64
-
Brian Meidrum, Roger Vigouroux, J. Brierley (1973)
Systemic factors and epileptic brain damage. Prolonged seizures in paralyzed, artificially ventilated baboons.Archives of neurology, 29 2
-
B. Siesjö (1981)
Cell Damage in the Brain: A Speculative SynthesisJournal of Cerebral Blood Flow & Metabolism, 1
-
T. Langfitt, L. Mchenry, M. Reivich, H. Wollman (1975)
Cerebral Circulation and Metabolism -
W. Longstreth, P. Diehr, T. Inui (1983)
Prediction of awakening after out-of-hospital cardiac arrest.The New England journal of medicine, 308 23
-
Ito Ito, Spatz Spatz, Walker Walker, Klatzo Klatzo (1975)
Experimental cerebral ischemia in Mongolian gerbils: 1. Light microscopic observationsActa Neuropathol (Berl), 32
-
H. Benveniste, J. Drejer, A. Schousboe, N. Diemer (1984)
Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral MicrodialysisJournal of Neurochemistry, 43
-
R. Auer, P. Hall, M. Ingvar, B. Siesjô (1986)
Hypotension as a complication of hypoglycemia leads to enhanced energy failure but no increase in neuronal necrosis.Stroke, 17 3
-
A. Chapman, B. Meldrum, B. Siesiö (1977)
CEREBRAL METABOLIC CHANGES DURING PROLONGED EPILEPTIC SEIZURES IN RATSJournal of Neurochemistry, 28
-
Kirino Kirino, Sano Sano (1984)
Selective vulnerability in the gerbil hippocampus following transient ischemiaActa Neuropathol (Berl), 62
-
Auer Rn, J. Hugh, E. Cosgrove, B. Curry (1989)
Neuropathologic findings in three cases of profound hypoglycemia.Clinical neuropathology, 8 2
-
M. Ingvar, B. Siesjö (1983)
Local blood flow and glucose consumption in the rat brain during sustained bicuculline‐induced seizuresActa Neurologica Scandinavica, 68
-
F. Johansen, M. Jørgensen, D. Lubitz, N. Diemer (1984)
Selective dendrite damage in hippocampal CA1 stratum radiatum with unchanged axon ultrastructure and glutamate uptake after transient cerebral ischaemia in the ratBrain Research, 291
-
J. Olney (1983)
Excitotoxins: An Overview -
B. Siesjö, G. Béndek, T. Koide, E. Westerberg, T. Wieloch (1985)
Influence of Acidosis on Lipid Peroxidation in Brain Tissues in vitroJournal of Cerebral Blood Flow & Metabolism, 5
-
S. Pavlakis, P. Phillips, S. Dimauro, D. Vivo, L. Rowland (1984)
Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: A distinctive clinical syndromeAnnals of Neurology, 16
-
B. Siesjö, M. Ingvar, E. Westerberg (1982)
The Influence of Bicuculline‐Induced Seizures on Free Fatty Acid Concentrations in Cerebral Cortex, Hippocampus, and CerebellumJournal of Neurochemistry, 39
-
M. Ingvar, Jaroslava Folbegrova, B. Siesjö (1987)
Metabolic Alterations Underlying the Development of Hypermetabolic Necrosis in the Substantia Nigra in Status EpilepticusJournal of Cerebral Blood Flow & Metabolism, 7
-
J. Sloper, Pauline Johnson, T. Powell (1980)
Selective degeneration of interneurons in the motor cortex of infant monkeys following controlled hypoxia: a possible cause of epilepsyBrain Research, 198
-
C. Agardh, J. Folbergrová, B. Siesjö (1978)
CEREBRAL METABOLIC CHANGES IN PROFOUND, INSULIN‐INDUCED HYPOGLYCEMIA, AND IN THE RECOVERY PERIOD FOLLOWING GLUCOSE ADMINISTRATIONJournal of Neurochemistry, 31
-
Tlars Hillered, Maj-lis Smith, B. Siesj
Journal of Cerebral Blood Flow and Metabolism Lactic Acidosis and Recovery of Mitochondrial Function following Forebrain Ischemia in the Rat -
Auer Auer, Wieloch Wieloch, Olsson Olsson, Siesjö Siesjö (1984)
The distribution of hypoglycemic brain damageActa Neuropathol (Berl), 64
-
S. Biasi, C. Frassoni, R. Spreafico (1986)
GABA immunoreactivity in the thalamic reticular nucleus of the rat. A light and electron microscopical studyBrain Research, 399
-
R. Collins, J. Olney (1982)
Focal cortical seizures cause distant thalamic lesions.Science, 218 4568
-
D. Pelligrino, L. Almquist, B. Siesjö (1981)
Effects of insulin-induced hypoglycemia on intracellular pH and impedance in the cerebral cortex of the ratBrain Research, 221
-
B. Siesjö (1988)
Acidosis and ischemic brain damage.Neurochemical pathology, 9
-
R. Sapolsky, W. Pulsinelli (1985)
Glucocorticoids potentiate ischemic injury to neurons: therapeutic implications.Science, 229 4720
-
M. Kiessling, Yaxia Xie, P. Kleihues (1984)
Regionally Selective Inhibition of Cerebral Protein Synthesis in the Rat During Hypoglycemia and RecoveryJournal of Neurochemistry, 43
-
Ali Abdul-Rahman, C. Agardh, B. Siesjö (1980)
Local cerebral blood flow in the rat during severe hypoglycemia, and in the recovery period following glucose injection.Acta physiologica Scandinavica, 109 3
-
Pulsinelli Pulsinelli, Levy Levy, Sigsbee Sigsbee (1983)
Increased damage after ischemic stroke in patients with hyperglycemia with or without diabetes mellitusAm J Med, 74
-
(1971)
Cyrotoxic effects of acidic and sulphur containing amino acids on the infant mouse central nervous system -
L. Wolfe (1982)
Eicosanoids: Prostaglandins, Thromboxanes, Leukotrienes, and Other Derivatives of Carbon‐20 Unsaturated Fatty AcidsJournal of Neurochemistry, 38
-
D. Monaghan, V. Holets, D. Toy, C. Cotman (1983)
Anatomical distributions of four pharmacologically distinct 3H-L-glutamate binding sitesNature, 306
-
Auer Auer, Ingvar Ingvar, Nevander Nevander (1986)
Early axonal lesion and preserved microvasculature in epilepsy‐induced hypermetabolic necrosis of the substantia nigraActa Neuropathol (Berl), 71
- Publisher
- Wiley
- Copyright
- Copyright © 1988 American Neurological Association
- ISSN
- 0364-5134
- eISSN
- 1531-8249
- DOI
- 10.1002/ana.410240602
- pmid
- 3061362
- Publisher site
- See Article on Publisher Site
Abstract
Ischemia, hypoglycemia, and epilepsy have long been thought to produce similar or identical brain damage. Further more, these insults have been assumed to be additive in their damaging effects. These notions have been based on neuropathological observations in the hippocampus and cerebral cortex, and on the tenet that energy failure (ischemia. hypoglycemia) and increased demand for energy (epilepsy) similarly give rise to selective neuronal neuronal mecrosis Recently, other bases for considering these three insults identical have grown out of observations that loss of calcium homeostasis is common to all and that an excitotoxic mechanism of selective neuronal necrosis exists in all three conditions. Fundamental differences between ischemia, hypoglycemia, and epilepsy include the underlying neurochemical changes induced, the neuronal revival times, the time course of neuronal death, the distribution of selective neuronal necrosis, and the likely excitotoxins released. Lactic acid accumulation, implicated in damage to the neuropil as well as to neuronal cell bodies, also occurs to different degrees and in different distributions in the three conditions. The degree and distribution of pannecrosis is thus also different in ischemia, hypoglycemia, and epilepsy.
Journal
Annals of Neurology – Wiley
Published: Dec 1, 1988