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- Publisher
- Wiley
- Copyright
- Copyright © 2008 Wiley Subscription Services
- ISSN
- 0951-4198
- eISSN
- 1097-0231
- DOI
- 10.1002/rcm.3572
- pmid
- 18438761
- Publisher site
- See Article on Publisher Site
Abstract
The aim of this paper is to review the factors which may affect breath 13CO2/12CO2 natural abundance in patients undergoing surgery or intensive care. Intravenous glucose administration is a major determinant of the 13CO2/12CO2 of breath as intravenous glucose preparations are almost all derived from cornstarch. In addition, the oxidation of endogenous substrates can affect the 13CO2/12CO2 ratio. During many endoscopic procedures, such as laparoscopic surgery, carbon dioxide insufflation is used to provide a working space. As medical CO2 is relatively depleted in 13CO2 compared with endogenous and exogenous metabolic CO2 sources, breath 13CO2/12CO2 measurements can be used to estimate CO2 absorption during these procedures. However, all these factors may also be affected by the bicarbonate pool, making a definitive attribution of changes in breath 13CO2/12CO2 to a single factor problematic. Copyright © 2008 John Wiley & Sons, Ltd.
Journal
Rapid Communications in Mass Spectrometry – Wiley
Published: Jan 15, 2008