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/lp/karger/tumor-necrosis-factor-and-lnterleukin-1-stimulated-intercellular-6MCCzIpY1e
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- Publisher
- Karger
- Copyright
- © 1992 S. Karger AG, Basel
- ISSN
- 1420-4096
- eISSN
- 1423-0143
- DOI
- 10.1159/000173466
- Publisher site
- See Article on Publisher Site
Abstract
The regulation of intercellular adhesion molecule-1 (ICAM-1) expression by renal tubular epithelial cells (TEC) has been studied in vitro. ICAM-1 expression in TEC is stimulated with phorbol 12-myristate 13-acetate (PMA), but not with forskolin, suggesting a role for protein kinase C (PKC) but not for protein kinase A (PKA). The tumor necrosis factor-Α- (TNF-Α) and interleukin-1 (IL-1)-stimulated ICAM-1 expression in TEC is blocked with the PKC/PKA inhibitor staurosporine, and also with the PKC-selective inhibitor calphostin C. The TNF-Α-stimulated ICAM-1 expression is resistant however to downregulation of PKC with PMA. The TNF-Α- and IL-1-stimulated ICAM-1 expression is also inhibited with the transcriptional inhibitor actinomycin D and with the protein synthesis inhibitor cycloheximide. Thus, ICAM-1 expression by TEC may involve a downregulation-resistant PKC which induces ICAM-1 expression at a transcriptional level.
Journal
Kidney and Blood Pressure Research – Karger
Published: Jan 1, 2008
Keywords: Intercellular adhesion molecule-1; Tubular epithelium; Cytokines; Protein kinase C