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l‐citrulline prevents asymmetric dimethylarginine‐mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells

l‐citrulline prevents asymmetric dimethylarginine‐mediated reductions in nitric oxide and... doi: 10.1111/cea.12802 Clinical & Experimental Allergy, 47, 190–199 © 2016 John Wiley & Sons Ltd ORIGINAL ARTICLE Asthma and Rhinitis L-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells 1 2 1 3 1 2 1 1 1 4 D. Winnica , L. G. Que , C. Baffi , H. Grasemann , K. Fiedler , Z. Yang , E. Etling , K. Wasil , S. E. Wenzel , B. Freeman and F. Holguin 1 2 Asthma Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA, Medicine, Duke University School of Medicine, Durham, NC, USA, 3 4 Respiratory Medicine, Hospital for Sick Children, Toronto, ON, Canada and Pharmacology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA Summary Clinical Background Asthma is associated with reduced systemic levels of L-arginine and increased asymmetric dimethylarginine (ADMA). This imbalance leads to nitric oxide synthase (NOS) uncoupling with reduced nitric oxide (NO) formation and greater oxidative and nitrosative Experimental stress. Whether this imbalance also occurs in bronchial epitheliumof asthmatics is unknown. Objectives We used primary human bronchial epithelial cells (HBECs) from asthmatics and Allergy healthy controls to evaluate: (i) ADMA-mediated NOS uncoupling reduces epithelial pro- duction of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical & Experimental Allergy Wiley

l‐citrulline prevents asymmetric dimethylarginine‐mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells

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References (38)

Publisher
Wiley
Copyright
Copyright © 2017 John Wiley & Sons Ltd
ISSN
0954-7894
eISSN
1365-2222
DOI
10.1111/cea.12802
pmid
27562295
Publisher site
See Article on Publisher Site

Abstract

doi: 10.1111/cea.12802 Clinical & Experimental Allergy, 47, 190–199 © 2016 John Wiley & Sons Ltd ORIGINAL ARTICLE Asthma and Rhinitis L-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells 1 2 1 3 1 2 1 1 1 4 D. Winnica , L. G. Que , C. Baffi , H. Grasemann , K. Fiedler , Z. Yang , E. Etling , K. Wasil , S. E. Wenzel , B. Freeman and F. Holguin 1 2 Asthma Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA, Medicine, Duke University School of Medicine, Durham, NC, USA, 3 4 Respiratory Medicine, Hospital for Sick Children, Toronto, ON, Canada and Pharmacology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA Summary Clinical Background Asthma is associated with reduced systemic levels of L-arginine and increased asymmetric dimethylarginine (ADMA). This imbalance leads to nitric oxide synthase (NOS) uncoupling with reduced nitric oxide (NO) formation and greater oxidative and nitrosative Experimental stress. Whether this imbalance also occurs in bronchial epitheliumof asthmatics is unknown. Objectives We used primary human bronchial epithelial cells (HBECs) from asthmatics and Allergy healthy controls to evaluate: (i) ADMA-mediated NOS uncoupling reduces epithelial pro- duction of

Journal

Clinical & Experimental Allergy – Wiley

Published: Feb 1, 2017

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