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Improving patient selection for selective internal radiation therapy of intra‐hepatic cholangiocarcinoma: A meta‐regression study

Improving patient selection for selective internal radiation therapy of intra‐hepatic... AbbreviationsC.I.confidence intervalcTACEconventional trans‐arterial chemo‐embolizationiCCAintra‐hepatic cholangiocarcinomaRECISTresponse evaluation criteria in solid tumoursSIRTselective internal radiation therapyKey pointsA systematic review and meta‐regression were performed to assess survivals that can be expected after selective internal radiation therapy (SIRT) for unresectable intra‐hepatic cholangiocarcinoma (iCCA) in various clinical conditions.This study population consisted of 224 patients from nine observational studies. The 1‐, 2‐ and 3‐year pooled survivals were 55.7%, 33.1% and 20.2%.Best survivals were estimated for mass‐forming iCCA (19.9 months), or naïve to SIRT (24 months) and receiving chemotherapy (19.5 months). In all other instances, median survivals were <12 months.The present results can provide some indications for future patient selection and prospective study planning.IntroductionIntrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver cancer after hepatocellular carcinoma. Although relatively infrequent, its incidence is increasing worldwide, accounting for up to 15% of primary liver cancers with a rate of about 2.1 per 100 000 people/y in western countries. The only treatment providing some survival expectations is currently represented by hepatic resection, being able to provide the 10% of possibility of being alive and free from the disease, 10 years after the treatment. Unfortunately, only 30%‐40% of iCCAs are diagnosed at a stage which meets the criteria for curative resection. If left untreated, iCCA patients have http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Liver International Wiley

Improving patient selection for selective internal radiation therapy of intra‐hepatic cholangiocarcinoma: A meta‐regression study

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References (41)

Publisher
Wiley
Copyright
© 2017 John Wiley & Sons A/S
ISSN
1478-3223
eISSN
1478-3231
DOI
10.1111/liv.13382
pmid
28177190
Publisher site
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Abstract

AbbreviationsC.I.confidence intervalcTACEconventional trans‐arterial chemo‐embolizationiCCAintra‐hepatic cholangiocarcinomaRECISTresponse evaluation criteria in solid tumoursSIRTselective internal radiation therapyKey pointsA systematic review and meta‐regression were performed to assess survivals that can be expected after selective internal radiation therapy (SIRT) for unresectable intra‐hepatic cholangiocarcinoma (iCCA) in various clinical conditions.This study population consisted of 224 patients from nine observational studies. The 1‐, 2‐ and 3‐year pooled survivals were 55.7%, 33.1% and 20.2%.Best survivals were estimated for mass‐forming iCCA (19.9 months), or naïve to SIRT (24 months) and receiving chemotherapy (19.5 months). In all other instances, median survivals were <12 months.The present results can provide some indications for future patient selection and prospective study planning.IntroductionIntrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver cancer after hepatocellular carcinoma. Although relatively infrequent, its incidence is increasing worldwide, accounting for up to 15% of primary liver cancers with a rate of about 2.1 per 100 000 people/y in western countries. The only treatment providing some survival expectations is currently represented by hepatic resection, being able to provide the 10% of possibility of being alive and free from the disease, 10 years after the treatment. Unfortunately, only 30%‐40% of iCCAs are diagnosed at a stage which meets the criteria for curative resection. If left untreated, iCCA patients have

Journal

Liver International – Wiley

Published: Jul 1, 2017

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