Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

α-Tocopherol as an antiretroviral therapy supplement for HIV-1-infected patients for increased lymphocyte viability

α-Tocopherol as an antiretroviral therapy supplement for HIV-1-infected patients for increased... Abstract The aim of our study was to evaluate the benefits of supplementation with 800mg/day of α-tocopherol with regard to cellular viability in HIV-1 seropositive patients undergoing anti-retroviral therapy. A total of 29 patients participated in the study, of whom 14 were given the supplement and 15 a placebo. The analyses were carried out before treatment commenced and after 60, 120 and 180days. The plasma levels ofHIV-1 RNA showed a significant decrease as a consequence of treatment time in the groups studied (p=0.0001), although the difference between the treatments over time was not verified (p=0.7343). The percentage of viable lymphocytes showed a significant increase as a consequence of treatment time in both groups studied (p=0.0002) and a significant difference between the treatments over time (p=0.0472). The percentage of lymphocytes in apoptosis showed a significant reduction over time (p=0.0003), as well as a significant difference between the treatments over time (p=0.0321). The significant increase in cellular viability indicates that supplementation with α-tocopherol offers an additional positive effect on cellular preservation in HIV-1 individuals undergoing anti-retroviral therapy; however, it represents an additional risk of anti-retroviral therapeutic failure, possibly due to drug-drug interaction involving up-regulation of metabolic clearance. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical Chemistry and Laboratory Medicine (CCLM) de Gruyter

α-Tocopherol as an antiretroviral therapy supplement for HIV-1-infected patients for increased lymphocyte viability

Download PDF
7 pages

Loading next page...
 
/lp/de-gruyter/tocopherol-as-an-antiretroviral-therapy-supplement-for-hiv-1-infected-78ZX1UYUWA

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
de Gruyter
Copyright
Copyright © 2005 by the
ISSN
1434-6621
eISSN
1437-4331
DOI
10.1515/CCLM.2005.068
pmid
15899652
Publisher site
See Article on Publisher Site

Abstract

Abstract The aim of our study was to evaluate the benefits of supplementation with 800mg/day of α-tocopherol with regard to cellular viability in HIV-1 seropositive patients undergoing anti-retroviral therapy. A total of 29 patients participated in the study, of whom 14 were given the supplement and 15 a placebo. The analyses were carried out before treatment commenced and after 60, 120 and 180days. The plasma levels ofHIV-1 RNA showed a significant decrease as a consequence of treatment time in the groups studied (p=0.0001), although the difference between the treatments over time was not verified (p=0.7343). The percentage of viable lymphocytes showed a significant increase as a consequence of treatment time in both groups studied (p=0.0002) and a significant difference between the treatments over time (p=0.0472). The percentage of lymphocytes in apoptosis showed a significant reduction over time (p=0.0003), as well as a significant difference between the treatments over time (p=0.0321). The significant increase in cellular viability indicates that supplementation with α-tocopherol offers an additional positive effect on cellular preservation in HIV-1 individuals undergoing anti-retroviral therapy; however, it represents an additional risk of anti-retroviral therapeutic failure, possibly due to drug-drug interaction involving up-regulation of metabolic clearance.

Journal

Clinical Chemistry and Laboratory Medicine (CCLM) – de Gruyter

Published: Apr 1, 2005

Keywords: antiretroviral therapy; apoptosis; cellular viability; HIV; oxidative stress; α-tocpherol

References

  • Supplementation with antioxidant vitamins prevents oxidative modification of DNA in lymphocytes of HIV - infected patients Free Radic
    Jaruga
  • Kinloch - de - The potential for CD cell increases in HIV - positive individuals who control viraemia with highly active anti - retroviral therapy
    Smith
  • Discordant CD T lymphocyte responses to anti - retroviral therapy for HIV infection are associated with ex - vivo rates of apoptosis
    Pitrak
  • Decreased antioxidant defence in individuals infected by the human immunodeficiency virus
    Treitinger
  • Role of reactive oxygen intermediates in activation - induced CD APO - ligand expression
    Bauer
  • Viral dynamics in human immunodeficiency virus type infection
    Wei
  • The biochemistry of apoptosis
    Hengartner
  • Effect of antioxidants on glucose metabolism and plasma lipids in HIV - infected subjects with lipoatrophy
    McComsey
  • Apoptosis : definition mechanisms and relevance to disease
    Saikumar
  • cell activation - induced and HIV tat - enhanced CD APO - ligand transcription involves NF - kappaB
    Li
  • Vitamin inhibits CD ligand expression and protects T cells from activation - induced cell death
    Li
  • Defying death after DNA damage
    Rich
  • Rapid turnover of plasma virions and CD lymphocytes in HIV - infection
    Ho
  • PKC - theta is required for TCR - induced NF - kappaB activation in mature but not immature T lymphocytes
    Sun
  • Initial increase in blood CD lym - phocytes after HIV anti - retroviral therapy reflectsredistribution from lymphoid tissues
    Bucy
  • Vitamin E : beyond antioxidant function
    Traber
  • Programmed cell death as a mechanism of CD and CD cell deletion in AIDS : molecular control and effect of highly active anti - retroviral therapy
    Gougeon
  • Tumor necrosis factor - alpha in human immunodeficiency virus - infected patients : correlations with opportunistic infections and immunologic status
    Constans
  • Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor - induced apoptosis and activation of nuclear transcription factor - kappaB and activated protein -
    Manna
  • Function and activation of NF - κB in the immune system
    Baeuerle
  • Flora PS Concurrent liquid chromatographic assay of retinol , alpha - tocopherol , beta - carotene , alpha - carotene lycopene and beta - cryptoxanthin in plasma , with tocopherol acetate as internal standard
    Thurnham
  • Reduction in T cell apoptosis in patients with HIV disease following anti - retroviral therapy
    Chavan
  • FADD , a novel death domain - containing protein , interacts with the death domain of Fas and initiates apoptosis
    Chinnaiyan
  • Daniel Mitochondria in HIV - - induced apoptosis
    Arnoult
  • Inhibition of cell proliferation by alpha - tocopherol Role of protein kinase C
    Boscoboinik
  • Vitamin nuclear receptors and xenobiotic metabolism
    Traber
  • Vitamin E activates gene expression via the pregnane X receptor
    Landes
  • NF - kappaB as a primary regulator of the stress response
    Mercurio
  • Anti - retroviral therapy reverses HIV - associated abnormalities in lymphocyte apoptosis
    Johnson
  • Oxidative stress and plasma antioxidant micronutrients in humans with HIV infection
    Allard
  • Effects of vitamin E and C supplementation on oxidative stress and viral load in HIV - infected subjects
    Allard
  • Ex vivo induction of apoptosis in lymphocytes is mediated by oxidative stress : role for lymphocyte loss in HIV infection Free Radic
    Dobmeyer
  • CD s deadly mission in the immune system
    Kramer
  • CD and CD T cell death during human immunodeficiency virus infection in vitro
    Blanco
  • Vitamin E and drug metabolism
    Brigelius