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Macrophage heterogeneity in atherosclerotic plaques

Macrophage heterogeneity in atherosclerotic plaques Jason L. Johnson and Andrew C. Newby Bristol Heart Institute, University of Bristol, Level 7, Purpose of review Bristol Royal Infirmary, Bristol, UK The varied behaviour of macrophages and foam cells during atherosclerosis and its Correspondence to Andrew C. Newby, Bristol Heart clinical sequelae prompt the question whether all these activities can be the property of Institute, University of Bristol, Level 7, Bristol Royal a single cell population. Infirmary, Bristol BS2 8HW, UK Tel: +44 117 342 3583; fax: +44 117 342 3581; Recent findings e-mail: [email protected] Subsets of monocytes with distinct patterns of surface markers and behaviours during Current Opinion in Lipidology 2009, 20:370–378 inflammation have recently been characterized and shown to have complementary roles during progression of atherosclerosis. A variety of macrophage phenotypes derived from these monocyte subsets in response to mediators of innate and acquired immunity have also been found in plaques. Based on functional properties and genomic signatures, they may have different impacts on facets of plaque development, including fibrous cap and lipid core formation. Summary Monocyte and macrophage phenotypic diversity is important in atherogenesis. More work is needed to define consistent marker sets for the different foam cell phenotypes in experimental animals and humans. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Lipidology Wolters Kluwer Health

Macrophage heterogeneity in atherosclerotic plaques

Newby, Andrew C
Current Opinion in Lipidology , Volume 20 (5) – Oct 1, 2009
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ISSN
0957-9672
eISSN
1473-6535
DOI
10.1097/MOL.0b013e3283309848
pmid
19741337
Publisher site
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Abstract

Jason L. Johnson and Andrew C. Newby Bristol Heart Institute, University of Bristol, Level 7, Purpose of review Bristol Royal Infirmary, Bristol, UK The varied behaviour of macrophages and foam cells during atherosclerosis and its Correspondence to Andrew C. Newby, Bristol Heart clinical sequelae prompt the question whether all these activities can be the property of Institute, University of Bristol, Level 7, Bristol Royal a single cell population. Infirmary, Bristol BS2 8HW, UK Tel: +44 117 342 3583; fax: +44 117 342 3581; Recent findings e-mail: [email protected] Subsets of monocytes with distinct patterns of surface markers and behaviours during Current Opinion in Lipidology 2009, 20:370–378 inflammation have recently been characterized and shown to have complementary roles during progression of atherosclerosis. A variety of macrophage phenotypes derived from these monocyte subsets in response to mediators of innate and acquired immunity have also been found in plaques. Based on functional properties and genomic signatures, they may have different impacts on facets of plaque development, including fibrous cap and lipid core formation. Summary Monocyte and macrophage phenotypic diversity is important in atherogenesis. More work is needed to define consistent marker sets for the different foam cell phenotypes in experimental animals and humans.

Journal

Current Opinion in Lipidology – Wolters Kluwer Health

Published: Oct 1, 2009

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