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The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of <i>Sox5</i> and <i>Sox6</i>

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte... Downloaded from genesdev.cshlp.org on October 21, 2021 - Published by Cold Spring Harbor Laboratory Press The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6 1,4 2,4 3 2,6 Haruhiko Akiyama, Marie-Christine Chaboissier, James F. Martin, Andreas Schedl, and 1,5 Benoit de Crombrugghe Department of Molecular Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA; Institute of Human Genetics, University of Newcastle, International Center for Life, Newcastle upon Tyne, Ne1 3BZ, UK; Alkek Institute of Biosciences and Technology, Texas A&M System Health Science Center, Houston, Texas 77030, USA To examine whether the transcription factor Sox9 has an essential role during the sequential steps of chondrocyte differentiation, we have used the Cre/loxP recombination system to generate mouse embryos in which either Sox9 is missing from undifferentiated mesenchymal cells of limb buds or the Sox9 gene is inactivated after chondrogenic mesenchymal condensations. Inactivation of Sox9 in limb buds before mesenchymal condensations resulted in a complete absence of both cartilage and bone, but markers for the different axes of limb development showed a normal pattern of expression. Apoptotic domains within the developing limbs were http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of <i>Sox5</i> and <i>Sox6</i>

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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.1017802
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Abstract

Downloaded from genesdev.cshlp.org on October 21, 2021 - Published by Cold Spring Harbor Laboratory Press The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6 1,4 2,4 3 2,6 Haruhiko Akiyama, Marie-Christine Chaboissier, James F. Martin, Andreas Schedl, and 1,5 Benoit de Crombrugghe Department of Molecular Genetics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030, USA; Institute of Human Genetics, University of Newcastle, International Center for Life, Newcastle upon Tyne, Ne1 3BZ, UK; Alkek Institute of Biosciences and Technology, Texas A&M System Health Science Center, Houston, Texas 77030, USA To examine whether the transcription factor Sox9 has an essential role during the sequential steps of chondrocyte differentiation, we have used the Cre/loxP recombination system to generate mouse embryos in which either Sox9 is missing from undifferentiated mesenchymal cells of limb buds or the Sox9 gene is inactivated after chondrogenic mesenchymal condensations. Inactivation of Sox9 in limb buds before mesenchymal condensations resulted in a complete absence of both cartilage and bone, but markers for the different axes of limb development showed a normal pattern of expression. Apoptotic domains within the developing limbs were

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Genes & Development – Unpaywall

Published: Nov 1, 2002

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