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- Publisher
- Springer Journals
- Copyright
- Copyright © 1997 by Kluwer Academic Publishers
- Subject
- Medicine & Public Health; Oncology
- ISSN
- 0167-594X
- eISSN
- 1573-7373
- DOI
- 10.1023/A:1005733416571
- Publisher site
- See Article on Publisher Site
Abstract
We report a 25-year old immunocompetent woman with a high grade primary non-Hodgkin‘s lymphoma of the central nervous system (PNHL-CNS) in whom the administration of dexamethasone alone during three months produced a complete clinical and radiological response lasting over four years. If complete remission of PNHL-CNS induced by glucocorticoids are well known, the opportunity to observe glucocorticoid-induced remission for a long period oftime without radio- and chemotherapy is rare. Only nine othercases of PNHL-CNS with complete remission induced by glucocorticoidslasting from 6 to 60 months, were found in the literature and aresummarized here. Duration of glucocorticoids therapeutic effect inPNHL-CNS is probably underestimated. Glucocorticoids cannotbe recommended as sole initial treatment for PNHL-CNS. However, we suggest standard therapies to be delayed in thosepatients responding completely to glucocorticoids where radio-and chemotherapy should be contraindicated (kidney, liver, bonemarrow failure, pregnancy).
Journal
Journal of Neuro-Oncology – Springer Journals
Published: Sep 15, 2004