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Antibiotic Prophylaxis Before Surgery vs After Cord Clamping in Elective Cesarean Delivery

Antibiotic Prophylaxis Before Surgery vs After Cord Clamping in Elective Cesarean Delivery ORIGINAL ARTICLE Antibiotic Prophylaxis Before Surgery vs After Cord Clamping in Elective Cesarean Delivery A Double-blind, Prospective, Randomized, Placebo-Controlled Trial Armin Witt, MD; Mehmet Do¨ner, MD; Ljubomir Petricevic, MD; Angelika Berger, MD; Peter Germann, MD; Georg Heinze, PhD; Clemens Tempfer, MD, MBA Context: Perioperative antibiotic prophylaxis during elec- Interventions: In group 1, cefazolin (2 g) was admin- tive cesarean delivery at term to reduce postoperative ma- istered 20 to 30 minutes before skin incision. In group ternal infectious morbidity is generally used but may not 2, cefazolin (2 g) was administered immediately after be effective on the basis of the available data. Also, the clamping of the cord. In group 3, placebo was adminis- optimal timing of prophylactic antibiotic administra- tered before skin incision. tion is unclear. Results: The primary outcome was observed in 18 of Objective: To compare the effectiveness of cefazolin ad- 370 women in group 1 (4.9%) and in 14 of 371 ministered before skin incision vs cefazolin adminis- women in group 2 (3.8%), whereas it was noted in 45 tered after umbilical cord clamping vs placebo in a 3-arm of 371 women in group 3 (12.1%) (P .001 for group randomized trial. The primary objective http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Surgery American Medical Association

Antibiotic Prophylaxis Before Surgery vs After Cord Clamping in Elective Cesarean Delivery

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References (16)

Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6254
eISSN
2168-6262
DOI
10.1001/archsurg.2011.725
pmid
22184305
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Antibiotic Prophylaxis Before Surgery vs After Cord Clamping in Elective Cesarean Delivery A Double-blind, Prospective, Randomized, Placebo-Controlled Trial Armin Witt, MD; Mehmet Do¨ner, MD; Ljubomir Petricevic, MD; Angelika Berger, MD; Peter Germann, MD; Georg Heinze, PhD; Clemens Tempfer, MD, MBA Context: Perioperative antibiotic prophylaxis during elec- Interventions: In group 1, cefazolin (2 g) was admin- tive cesarean delivery at term to reduce postoperative ma- istered 20 to 30 minutes before skin incision. In group ternal infectious morbidity is generally used but may not 2, cefazolin (2 g) was administered immediately after be effective on the basis of the available data. Also, the clamping of the cord. In group 3, placebo was adminis- optimal timing of prophylactic antibiotic administra- tered before skin incision. tion is unclear. Results: The primary outcome was observed in 18 of Objective: To compare the effectiveness of cefazolin ad- 370 women in group 1 (4.9%) and in 14 of 371 ministered before skin incision vs cefazolin adminis- women in group 2 (3.8%), whereas it was noted in 45 tered after umbilical cord clamping vs placebo in a 3-arm of 371 women in group 3 (12.1%) (P .001 for group randomized trial. The primary objective

Journal

JAMA Surgery – American Medical Association

Published: Dec 1, 2011

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