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Precisely defining high‐risk operable head and neck tumors based on rtog #85‐03 and #88‐24: Targets for postoperative radiochemotherapy?

Precisely defining high‐risk operable head and neck tumors based on rtog #85‐03 and #88‐24:... Background Local‐regional recurrence of disease remains the major obstacle to cure of advanced head and neck cancers. Methods This investigation reviewed data derived from Radiation Therapy Oncology Group (RTOG) protocols #85‐03 and #88‐24 to identify characteristics of tumors that predicted local‐regional recurrence of disease following surgery and postoperative radiotherapy (RT). Results The presence of tumor in two or more lymph nodes, and/or extracapsular spread of nodal disease, and/or microscopic‐size tumor involvement of the surgical margins of resection imparts a high risk of local‐regional (L‐R) relapse. Our data also support the hypothesis that, following surgery, the concurrent addition of chemotherapy (CT) to RT may increase the likelihood of L‐R control of disease for patients who have these high‐risk characteristics. Conclusion A prospective trial of surgery followed by concurrent RT and CT is warranted for patients who have high‐risk characteristics found at surgery. © 1998 John Wiley & Sons, Inc. Head Neck 20: 588–594, 1998. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Head & Neck: Journal for the Sciences & Specialties of the Head and Neck Wiley

Precisely defining high‐risk operable head and neck tumors based on rtog #85‐03 and #88‐24: Targets for postoperative radiochemotherapy?

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References (12)

Publisher
Wiley
Copyright
Copyright © 1998 John Wiley & Sons, Inc.
ISSN
1043-3074
eISSN
1097-0347
DOI
10.1002/(SICI)1097-0347(199810)20:7<588::AID-HED2>3.0.CO;2-F
Publisher site
See Article on Publisher Site

Abstract

Background Local‐regional recurrence of disease remains the major obstacle to cure of advanced head and neck cancers. Methods This investigation reviewed data derived from Radiation Therapy Oncology Group (RTOG) protocols #85‐03 and #88‐24 to identify characteristics of tumors that predicted local‐regional recurrence of disease following surgery and postoperative radiotherapy (RT). Results The presence of tumor in two or more lymph nodes, and/or extracapsular spread of nodal disease, and/or microscopic‐size tumor involvement of the surgical margins of resection imparts a high risk of local‐regional (L‐R) relapse. Our data also support the hypothesis that, following surgery, the concurrent addition of chemotherapy (CT) to RT may increase the likelihood of L‐R control of disease for patients who have these high‐risk characteristics. Conclusion A prospective trial of surgery followed by concurrent RT and CT is warranted for patients who have high‐risk characteristics found at surgery. © 1998 John Wiley & Sons, Inc. Head Neck 20: 588–594, 1998.

Journal

Head & Neck: Journal for the Sciences & Specialties of the Head and Neck – Wiley

Published: Oct 1, 1998

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