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Don't give up on GWAS

Don't give up on GWAS Molecular Psychiatry (2012) 17, 2–8 & 2012 Macmillan Publishers Limited All rights reserved 1359-4184/12 www.nature.com/mp LETTERS TO THE EDITOR Molecular Psychiatry (2012) 17, 2–3; doi:10.1038/mp.2011.94; intermediate: slightly worse than multiple sclerosis published online 9 August 2011 and age-related macular degeneration (0.5), similar to lung cancer (0.4), and slightly better than type 2 diabetes mellitus (0.3), breast cancer (0.2), and body Psychiatric diseases are of major public health impor- mass (0.1). The pace of gene discovery for schizo- tance owing to their enormous morbidity, mortality phrenia is thus typical. and personal/societal cost. Little is known for certain Empirical data from other complex traits can about the etiology of these diseases, and treatment, project what might be discovered if we had larger detection and prevention strategies are not directed sample sizes for schizophrenia and bipolar disorder. by knowledge of pathophysiology. As family history With sample sizes four times larger than those is a major risk factor, genetic approaches are critically currently available, 30–60 more loci might be identi- important for most psychiatric disorders. fied for schizophrenia and bipolar disorder. This new The initial set of genome-wide association studies knowledge would greatly improve pathway analyses (GWAS) using microarrays to test for the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Molecular Psychiatry Springer Journals

Don't give up on GWAS

Sullivan, P
Molecular Psychiatry , Volume 17 (1) – Aug 9, 2011
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Publisher
Springer Journals
Copyright
Copyright © 2012 by Macmillan Publishers Limited
Subject
Medicine & Public Health; Medicine/Public Health, general; Psychiatry; Neurosciences; Behavioral Sciences; Pharmacotherapy; Biological Psychology
ISSN
1359-4184
eISSN
1476-5578
DOI
10.1038/mp.2011.94
Publisher site
See Article on Publisher Site

Abstract

Molecular Psychiatry (2012) 17, 2–8 & 2012 Macmillan Publishers Limited All rights reserved 1359-4184/12 www.nature.com/mp LETTERS TO THE EDITOR Molecular Psychiatry (2012) 17, 2–3; doi:10.1038/mp.2011.94; intermediate: slightly worse than multiple sclerosis published online 9 August 2011 and age-related macular degeneration (0.5), similar to lung cancer (0.4), and slightly better than type 2 diabetes mellitus (0.3), breast cancer (0.2), and body Psychiatric diseases are of major public health impor- mass (0.1). The pace of gene discovery for schizo- tance owing to their enormous morbidity, mortality phrenia is thus typical. and personal/societal cost. Little is known for certain Empirical data from other complex traits can about the etiology of these diseases, and treatment, project what might be discovered if we had larger detection and prevention strategies are not directed sample sizes for schizophrenia and bipolar disorder. by knowledge of pathophysiology. As family history With sample sizes four times larger than those is a major risk factor, genetic approaches are critically currently available, 30–60 more loci might be identi- important for most psychiatric disorders. fied for schizophrenia and bipolar disorder. This new The initial set of genome-wide association studies knowledge would greatly improve pathway analyses (GWAS) using microarrays to test for the

Journal

Molecular Psychiatry – Springer Journals

Published: Aug 9, 2011

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