Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wolters-kluwer-health/interferon-gamma-decreases-hepatic-stellate-cell-activation-and-8sCJoDmGZq
References (127)
-
SL Friedman, FJ Roll, J Boyles, DM Arenson, DM Bissell (1989)
Maintenance of differentiated phenotype of cultured rat hepatocytes by basement membrane matrix, 264
-
Acti-43. Ramadori G. The stellate cell of the liver. New insights into -
PE Danielson, S Forss‐Petter, MA Brow, L Calavetta, J Douglass, RJ Milner, JG Sutcliffe (1988)
plB15: A cDNA clone of the rat mRNA encoding for cyclophilin, 7
-
JE Schwarzbauer, JW Tamkun, IR Lemischka, RO Hynes (1983)
Three different fibronectin mRNAs arise by alternative splicing within the coding region, 35
-
(1984)
of laminin B chain cDNAs reveals C-terminal regions of coiled-Surrenti C. Acetaldehyde regulates the gene expression of macoil alpha-helix -
MJ Czaja, RF Weiner, S Takahashi, MA Giambrone, PH Van der Meide, H Schellekens, L Biempica (1989)
Gamma‐interferon treatment inhibits collagen deposition in murine schistosomiasis, 10
-
P Chomczynski, N Sacchi (1987)
Single step‐method of RNA isolation by acid guanidinium thiocyanate‐phenol‐chloroform extraction, 162
-
Chronic iron overload causes activation of rat lipocytes in 10762 . vivo -
(1994)
Ito cell heterogeneity : Desmin negative Ito cells in normal lainen ER . Gene expression of type I , III and IV collagens in rat liver -
MG Bachem, D Meyer, R Melchior, KM Sell, AM Gressner (1992)
Activation of rat liver perisinusoidal lipocytes by transforming growth factor derived from myofibroblastlike cells, 89
-
PA Todd, KL Goa (1992)
Interferon‐gamma. A review of its pharmaco‐logic and therapeutic potential in chronic granulomatous disease, 43
-
(1989)
Collagen types in norgrowth factor beta-1 on cell proliferation and collagen formation mal and cirrhotic liver. Gastroenterology 1979;76:710-719. by cultured fat-storing cells -
(1988)
encoding for cyclophilin -
S Milani, H Herbst, D Schuppan, KY Kim, EO Riechen, H Stein (1990)
Cellular localization of type I, III. and IV procollagen gene transcripts in normal and fibrotic human liver, 137
-
G Ramadori (1991)
The stellate cell of the liver. New insights into pathophysiology of an intriguing cell, 61
-
(1991)
The sistemic administration of bon tetrachloride - injured rat liver -
Extracellular matrix gene expression -
R Mancini, A Benedetti, AM Jezequel (1994)
An interleukin‐1 receptor antagonist decreases fibrosis induced by dimethylnitrosamine in rat liver, 424
-
(1987)
Immunocytochemical detection of desmin in fat- EP. Gamma interferon inhibits collagen synthesis in vivo in the storing cells (Ito cells) -
H Tsukamoto, M Matsuoka, SW French (1990)
Experimental models of hepatic fibrosis: a review, 10
-
(1992)
Departgrowth factor derived from myofibroblastlike cells -
AM Jezequel, G Ballardini, R Mancini, F Paolucci, FB Bianchi, F Orlandi (1990)
Modulation of extracellular matrix components during dimethylnitrosamine‐induced cirrhosis, 11
-
Selective inhibition -
G Svegliati Baroni, E Baraona, A Rosman, CS Lieber (1994)
Collagenacetal dehyde adducts in alcoholic and nonalcoholic liver diseases, 20
-
Regulation of extracellular matrix synthesis by transforming growth factor b 1 in human fat - storingfor the helpful discussion . cells -
RD Granstein, MR Deak, SL Jacques, RJ Margolis, TJ Flotte, D Whitaker, FH Long (1989)
The sistemic administration of gamma interferon inhibits collagen synthesis and acute inflammation in a murine skin wounding model, 93
-
B Clement, H Emonard, M Rissel, M Druguet, J‐A Grimaud, D Herbage, M Bourel (1984)
Cellular origin of collagen and fibronectin in the liver, 30
-
; 4 : 709 - 714 . mouse -
A Casini, M Pinzani, S Milani, C Grappone, G Galli, AM Jezequel, D Schuppan (1993)
Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat‐storing cells, 105
-
Y Tanaka, K Mak, CS Lieber (1990)
Immunocytochemical detection of proliferating lipocytes in regenerating rat liver, 160
-
(1991)
Phenotypic modulation in lipocytes in experimental 33 -
OH Lowry, NJ Rosebrough, AL Farr, RJ Randall (1951)
Protein measurement with the Folin phenol reagent, 195
-
C Genovese, D Rowe, B Kream (1984)
Construction of DNA sequences complementary to rat 1 and 2 collagen mRNA and their use in studying the regulation of type I collagen synthesis by 1,25‐dihydroxyvitamin D, 23
-
A. Gressner (1994)
Perisinusoidal lipocytes and fibrogenesis.Gut, 35
-
DP Barlow, NM Green, M Kurkinen, BLM Hogan (1984)
Sequencing of laminin B chain cDNAs reveals C‐terminal regions of coiled‐coil alpha‐helix, 3
-
TC Peterson (1993)
Pentoxifylline prevents fibrosis in an animal model and inhibits platelet‐derived growth factor‐driven proliferation of fibroblasts, 17
-
(1994)
Interferon - gamma . A review of its pharmaco - acetaldehyde adducts in alcoholic and nonalcoholic liver dis - logic and therapeutic potential in chronic granulomatous diseases -
(1994)
J-A, characterization of a receptor for tissue ferritin on activated rat -
JJ Maher, RF McGuire (1990)
Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo, 86
-
(1989)
Activation-dependent treatment inhibits collagen deposition in murine schistosomiacontractility of rat hepatic lipocytes in culture and in vivo -
L Ala‐Kokko, F Stenback, L Ryhanen (1989)
Preventive effect of malotilate on dimethylnitrosamine‐induced liver fibrosis in the rat, 113
-
(1985)
A dimethylnitrosamine-induced model of cirrhosis and portal H. Cellular localization of type I, III, and IV procollagen gene hypertension in the rat -
(1983)
Three normal rat liver release a neutral metalloproteinase that de - different fibronectin mRNAs arise by alternative splicing within grades basement membrane ( type IV ) collagen -
(1990)
Activation of cultured rat hepatic ing dimethylnitrosamine-induced cirrhosis -
JM Seyer, ET Hutcheson, AH Kang (1977)
Collagen polymorphism in normal and cirrhotic human liver, 59
-
G Ballardini, M Fallani, G Biagini, F Bianchi, E Pisi (1988)
Desmin and actin in the identification of Ito cells and monitoring their evolution to myofibroblasts in experimental liver fibrosis, 56
-
(1987)
Single step - method of RNA isolation of prostaglandin E 1 analog reduces rat hepatic and Ito cell colla - by acid guanidinium thiocyanate - phenol - chloroform extraction -
Y Tanaka, T Nouchi, M Yamane, T Irie, H Miyakawa, C Sato, F Marumo (1991)
Phenotypic modulation in lipocytes in experimental liver fibrosis, 164
-
(1970)
Cleavage of structural proteins during the assem - proteinases - 1 . Implication for regulation of matrix degradationbly of the head of bacteriophage T -
(1988)
p1B15: A cDNA clone of the rat mRNA 71 -
S Milani, H Herbst, D Schuppan, K Young Kim, E Riecken, H Stein (1990)
Procollagen expression by nonparenchymal rat liver cells in experimental biliary fibrosis, 98
-
(1984)
Acetaldehyde regulates the gene expression of ma - coil alpha - helix -
M Pinzani, V Carloni, F Marra, D Riccardi, G Laffi, P Gentilini (1994)
Biosynthesis of platelet‐activating factor and its 10‐Acyl analogue by liver fat‐storing cells, 106
-
(1951)
Protein meaH . Procollagen expression by nonparenchymal rat liver cells in surement with the Folin phenol reagent -
RD Granstein, GF Murphy, RJ Margolis, MH Byrne, EP Amento (1987)
Gamma interferon inhibits collagen synthesis in vivo in the mouse, 79
-
DC Rockey, JJ Maher, WR Jarnagin, G Gabbiani, SL Friedman (1992)
Inhibition of rat hepatic lipocytes activation in culture by interferon‐gamma, 16
-
(1987)
Preventive effect of malo - matosis -
Department of 23 -
(1986)
matrix proteins: Role of fat-storing cells in fibrogenesis. Semin 28 -
SA Jimenez, B Freundlich, J Rosenbloom (1984)
Selective inhibition of human diploid fibroblast collagen synthesis by interferons, 74
-
M Ruiz‐Moren, MJ Rua, G Moraleda, L Guardia, A Moreno, V Carreno (1992)
Treatment with interferon gamma versus interferons alfa and gamma in children with chronic hepatitis B, 90
-
F. Marra, A. Valente, M. Pinzani, H. Abboud (1993)
Cultured human liver fat-storing cells produce monocyte chemotactic protein-1. Regulation by proinflammatory cytokines.The Journal of clinical investigation, 92 4
-
Differential effects of interleukin-1, tumor necrosis factor alpha and transforming -
(1985)
and total protein determination in formalin-fixed paraffin-em-160:129-134. bedded sections -
GA Ramm, RS Britton, R O'Neill, BR Bacon (1994)
Identification and characterization of a receptor for tissue ferritin on activated rat lipocytes, 94
-
AM Bolinger, MA Taeubel (1992)
Recombinant interferon‐gamma for treatment of chronic granulomatous disease and other disorders, 11
-
Detlef Schuppan (1990)
Structure of the Extracellular Matrix in Normal and Fibrotic Liver: Collagens and GlycoproteinsSeminars in Liver Disease, 10
-
MB Goldring, LJ Sandell, ML Stephenson, SM Krane (1986)
Immune interferon suppresses levels of procollagen mRNA and type III collagen synthesis in cultured human articular and costal chondrocytes, 261
-
JJ Maher, SL Friedman, FJ Roll, DM Bissell (1988)
Immunolocaliza‐tion of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture, 94
-
(1985)
Hepatic lipocytes: of human diploid fibroblast collagen synthesis by interferons. J The principal collagen producing cells of normal rat liver -
JP Iredale, G Murphy, RM Hembry, SL Friedman, MJP Arthur (1992)
Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases‐1. Implication for regulation of matrix degradation in liver, 90
-
DWA Beno, R Espinal, BM Edelstein, BH Davis (1993)
Administration of prostaglandin E1 analog reduces rat hepatic and Ito cell collagen gene expression and collagen accumulation after bile duct ligation injury, 17
-
(1988)
cine in mice -
UK Laemmli (1970)
Cleavage of structural proteins during the assembly of the head of bacteriophage T, 227
-
(1990)
A simple micromethod for collagen proliferating lipocytes in regenerating rat liver -
DD Smith, M Gowen, GR Mundy (1987)
Effects of interferon‐gamma and other cytokines on collagen synthesis in fetal rat bones cultures, 120
-
Lipocytes from -
(1994)
characterization of a receptor for tissue ferritin on activated ratHerbage D , Bourel M , et al . Cellular origin of collagen and fibro - lipocytes -
M Rojkind, MA Giambrone, L Biempica (1979)
Collagen types in normal and cirrhotic liver, 76
-
A. Jezequel, R. Mancini, M. Rinaldesi, G. Macarri, C. Venturini, F. Orlandi (1987)
A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat.Journal of hepatology, 5 2
-
(1986)
Cellular sources of noncollagenous drocytes -
(1984)
Transformation of lipocytes to transitional cells. Gastroenterol-32 -
A Casini, E Ceni, R Salzano, G Galli, S Milani, D Schuppan, C Surrenti (1994)
Acetaldehyde regulates the gene expression of matrix metalloproteinases‐1 and −2 in human fat‐storing cells, 55
-
(1991)
quantitation and proliferation kinetics of fat-storing cells -
(1993)
Immunetion and the molecular pathogenesis of cirrhosis -
SA Jenkins, A Grandison, JN Baxter, DW Day, I Taylor, R Shields (1985)
A dimethylnitrosamine‐induced model of cirrhosis and portal hypertension in the rat, 1
-
DM Hyde, TS Henderson, SN Giri, NK Tyler, MY Stovall (1988)
Effect of murine gamma interferon on the cellular response to bleomycine in mice, 14
-
(1994)
Acet - logue by liver fat - storing cells -
(1992)
Vita - Inhibition of rat hepatic lipocytes activation in culture by inter - minA containing lipocytes and formation of type III collagen in feron - gamma -
D Fernandez‐Munoz, C Caramelo, JC Santos (1985)
Sistemic and splanchnic hemodynamic disturbances in conscious rats with experimental liver cirrhosis without ascites, 249
-
JJ Maher, C Tzagarakis (1994)
Partial cloning of the M subunit of laminin from adult rat lipocytes: Expression of the M subunit by cells isolated from normal and injured liver, 19
-
(1989)
Bacon by basement membrane matrix -
F Powrie, RL Coffman (1993)
Cytokine regulation of T‐cell function: Potential for therapeutic intervention, 14
-
(1993)
Collagen polymorphism -
E. Kovacs (1991)
Fibrogenic cytokines: the role of immune mediators in the development of scar tissue.Immunology today, 12 1
-
(1990)
Experimental modelsvia induction of platelet - derived growth factor receptors -
Biosynthesis of platelet-activating factor and its 10-Acyl ana -
(1991)
gamma interferon inhibits collagen synthesis and acute inflam-1202. mation in a murine skin wounding model -
S. Friedman (1993)
The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment StrategiesThe New England Journal of Medicine, 328
-
SL Friedman, MJP Arthur (1989)
Activation of cultured rat hepatic lipocytes by Kuppfer cell conditioned medium: Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet‐derived growth factor receptors, 84
-
G Ballardini, P Groff, L Badiali De Giorgi, D Schuppan, FB Bianchi (1994)
Ito cell heterogeneity: Desmin negative Ito cells in normal rat liver, 19
-
Y Yokoi, T Namihisa, H Kuroda, I Komatsu, A Miyazaki, S Wata‐nabe, K Usui (1984)
Immunocytochemical detection of desmin in fat‐storing cells (Ito cells), 4
-
(1989)
lipocytes by Kuppfer cell conditioned medium: Direct enhance-206-214. ment of matrix synthesis and stimulation of cell proliferation 42 -
SL Friedman (1993)
The cellular basis of hepatic fibrosis, 25
-
Roger Williams, M. Davis (1977)
Alcoholic liver injuryProceedings of the Nutrition Society, 47
-
(1993)
Sistemic and Regulation by inflammatory cytokines -
(1988)
Monoclonal antibody to 5 - bromo and 5 - iododeoxy - evolution to myofibroblasts in experimental liver fibrosis . Vir - uridine : A new reagent for detection of DNA replication -
A Geerts, JM Lazou, P De Bleser, E Wisse (1991)
Tissue distribution, quantitation and proliferation kinetics of fat‐storing cells in carbon tetrachloride‐injured rat liver, 13
-
AM Gressner, MG Bachem (1990)
Cellular sources of noncollagenous matrix proteins: Role of fat‐storing cells in fibrogenesis, 10
-
A Lopez‐De Leon, M Rojkind (1985)
A simple micromethod for collagen and total protein determination in formalin‐fixed paraffin‐embedded sections, 33
-
DA Brenner, J Westwick, M Breindl (1993)
Type I collagen gene regulation and the molecular pathogenesis of cirrhosis, 264
-
A. Pietrangelo, R. Gualdi, G. Casalgrandi, A. Geerts, P. Bleser, G. Montosi, E. Ventura (1994)
Enhanced hepatic collagen type I mRNA expression into fat‐storing cells in a rodent model of hemochromatosisHepatology, 19
-
M Matsuoka, NT Pham, H Tsukamoto (1989)
Differential effects of interleukin‐1, tumor necrosis factor alpha and transforming growth factor beta‐1 on cell proliferation and collagen formation by cultured fat‐storing cells, 9
-
L Ala‐Kokko, T Pihlajaniemi, CJ Myers, KI Kivirikko, ER Savolainen (1987)
Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat, 244
-
(1993)
aldehyde-collagen adducts in N-nitrosodimethylamine-induced liver cirrhosis -
KM Mak, MA Leo, CS Lieber (1984)
Alcoholic liver injury in baboons: Transformation of lipocytes to transitional cells, 87
-
SL Friedman, JF Roll, J Boyles, DM Bissell (1985)
Hepatic lipocytes: The principal collagen producing cells of normal rat liver, 82
-
A Geerts, R Vrijsen, J Rauterberger, A Burt, P Schellink, E Wisse (1989)
In vitro differentiation of fat‐storing cells parallels marked increase of collagen synthesis and secretion, 9
-
G Kent, S Gay, T Inohue, R Bahu, OT Minick, H Popper (1976)
Vitamin‐A containing lipocytes and formation of type III collagen in liver injury, 73
-
(1977)
Cytokine regulation of T - cell function : normal and cirrhotic human liver -
DC Rockey, CN Housset, SL Friedman (1993)
Activation‐dependent contractility of rat hepatic lipocytes in culture and in vivo, 92
-
(1990)
Or - increases preferentially in rat lipocytes and sinusoidal endothe - landi F . Quantitative analysis of proliferating sinusoidal cells in lial cells during hepatic fibrosis in vivo -
(1987)
Differential effects of gamma-interferon on collagen and fibro-10:1-10. nectin gene expression -
R Mancini, AM Jezequel, A Benedetti, F Paolucci, L Trozzi, F Orlandi (1992)
Quantitative analysis of proliferating sinusoidal cells in dimethylnitrosamine‐induced cirrhosis. An immunohistochemi‐cal study, 15
-
HG Gratzner (1982)
Monoclonal antibody to 5‐bromo and 5‐iododeoxyuridine: A new reagent for detection of DNA replication, 218
-
MJP Arthur, SL Friedman, FJ Roll, DM Bissell (1989)
Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen, 84
-
(1993)
Type I collagen gene
- Publisher
- Wolters Kluwer Health
- Copyright
- Copyright © 1996 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0270-9139
- eISSN
- 1527-3350
- DOI
- 10.1002/hep.510230538
- pmid
- 8621153
- Publisher site
- See Article on Publisher Site
Abstract
Interferon gamma (IFN‐γ) inhibits in vitro the activation of hepatic stellate cells (HSC), the primary extracellular matrix‐producing cells in liver fibrosis. This study was undertaken to determine in vivo the effect of IFN‐γ in the rat model of liver fibrosis induced by dimethylnitrosamine (DMN), where HSC activation represents an early response to cell injury. Rats were killed after 1 or 3 weeks of treatment with DMN, IFN‐γ, DMN + IFN‐γ, or saline. Immunohistochemistry was used to identify proliferating (desmin‐ positive/bromodeoxyuridine (BrdU)‐positive cells) and activated (α‐ smooth‐muscle actin [α‐SMA]‐positive cells) HSCs. Collagen deposition was determined colorimetrically and by morphometry. The parenchymal extension of desmin‐ and actin‐positive cells and of fibrotic tissue was measured by point‐counting technique and expressed as a percentage of area. Western blot was used to determine laminin and fibronectin accumulation. The levels of messenger RNA (mRNA) for procollagen type I, fibronectin, and laminin were evaluated by Northern blot. No differences were observed in rats treated with either saline or IFN‐γ alone. IFN‐γ reduced HSC activation induced by liver injury, as shown by the decreased number of proliferating HSC and the reduction of parenchymal area occupied by α‐SMA‐positive cells observed in DMN + IFN‐γ‐treated animals compared with the DMN group. This was associated with reduced collagen, laminin, and fibronectin accumulation and lower levels of mRNA for procollagen type I, fibronectin, and laminin in the DMN + IFN‐γ group. Thus, this study indicates that IFN‐γ reduces extracellular matrix deposition in vivo by inhibition of HSC activation.
Journal
Hepatology – Wolters Kluwer Health
Published: May 1, 1996