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BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization

BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization Brain-derived neurotrophic factor (BDNF), like other neurotrophins, is a polypeptidic factor initially regarded to be responsible for neuron proliferation, differentiation and survival, through its uptake at nerve terminals and retrograde transport to the cell body 1 . A more diverse role for BDNF has emerged progressively from observations showing that it is also transported anterogradely 2,3 , is released on neuron depolarization 1 , and triggers rapid intracellular signals 4 and action potentials in central neurons 5 . Here we report that BDNF elicits long-term neuronal adaptations by controlling the responsiveness of its target neurons to the important neurotransmitter, dopamine. Using lesions and gene-targeted mice lacking BDNF, we show that BDNF from dopamine neurons is responsible for inducing normal expression of the dopamine D3 receptor in nucleus accumbens 6,7,8 both during development and in adulthood. BDNF from corticostriatal neurons 3 also induces behavioural sensitization, by triggering overexpression of the D3 receptor in striatum of hemiparkinsonian rats 9 . Our results suggest that BDNF may be an important determinant of pathophysiological conditions such as drug addiction 10 , schizophrenia 11 or Parkinson's disease 12 , in which D3 receptor expression is abnormal. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization

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References (86)

Publisher
Springer Journals
Copyright
Copyright © 2001 by Macmillan Magazines Ltd.
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/35075076
Publisher site
See Article on Publisher Site

Abstract

Brain-derived neurotrophic factor (BDNF), like other neurotrophins, is a polypeptidic factor initially regarded to be responsible for neuron proliferation, differentiation and survival, through its uptake at nerve terminals and retrograde transport to the cell body 1 . A more diverse role for BDNF has emerged progressively from observations showing that it is also transported anterogradely 2,3 , is released on neuron depolarization 1 , and triggers rapid intracellular signals 4 and action potentials in central neurons 5 . Here we report that BDNF elicits long-term neuronal adaptations by controlling the responsiveness of its target neurons to the important neurotransmitter, dopamine. Using lesions and gene-targeted mice lacking BDNF, we show that BDNF from dopamine neurons is responsible for inducing normal expression of the dopamine D3 receptor in nucleus accumbens 6,7,8 both during development and in adulthood. BDNF from corticostriatal neurons 3 also induces behavioural sensitization, by triggering overexpression of the D3 receptor in striatum of hemiparkinsonian rats 9 . Our results suggest that BDNF may be an important determinant of pathophysiological conditions such as drug addiction 10 , schizophrenia 11 or Parkinson's disease 12 , in which D3 receptor expression is abnormal.

Journal

Nature – Springer Journals

Published: May 3, 2001

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