Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Effect of Substance P on Various Vascular Beds in the Dog

Effect of Substance P on Various Vascular Beds in the Dog Using the electromagnetic flowmeter technique, the blood flow in the aorta, carotid, hepatic, superior mesenteric, renal and femoral arteries and portal vein was recorded during continuous i.v. infusion of synthetic Substance P (SP) in 8 dogs. Systemic and portal blood pressures were recorded. A significant decrease in mean arterial blood pressure was recorded at infusion of SP in the femoral vein at a rate of 2.5 ng × min‐1× kg b.w.‐1 or higher. Portal venous blood pressure increased. A rapid increase in the carotid, hepatic, mesenteric and portal blood flow was obtained at infusion rates of 1.2 ng × min‐1× kg b.w.‐1 or higher. The femoral artery responded with a late, transient increase in flow, with a return to the base level while the infusion was still in progress. The renal artery blood flow decreased slightly at low infusion rates and increased at higher. At SP infusions in the portal vein the infusion rate had to be increased to 20 ng × min‐1× kg b.w.‐1 or higher before any general vascular reactions were recorded, indicating that the liver has a high capacity for inactivating SP. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Physiologica Wiley

Effect of Substance P on Various Vascular Beds in the Dog

Hallberg, Dag; Pernow, Bengt
Acta Physiologica , Volume 93 (2) – Feb 1, 1975
Download PDF
9 pages

Loading next page...
 
/lp/wiley/effect-of-substance-p-on-various-vascular-beds-in-the-dog-9Sn4aJaPx0

References (27)

Publisher
Wiley
Copyright
Copyright © 1975 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1748-1708
eISSN
1748-1716
DOI
10.1111/j.1748-1716.1975.tb05816.x
pmid
1146575
Publisher site
See Article on Publisher Site

Abstract

Using the electromagnetic flowmeter technique, the blood flow in the aorta, carotid, hepatic, superior mesenteric, renal and femoral arteries and portal vein was recorded during continuous i.v. infusion of synthetic Substance P (SP) in 8 dogs. Systemic and portal blood pressures were recorded. A significant decrease in mean arterial blood pressure was recorded at infusion of SP in the femoral vein at a rate of 2.5 ng × min‐1× kg b.w.‐1 or higher. Portal venous blood pressure increased. A rapid increase in the carotid, hepatic, mesenteric and portal blood flow was obtained at infusion rates of 1.2 ng × min‐1× kg b.w.‐1 or higher. The femoral artery responded with a late, transient increase in flow, with a return to the base level while the infusion was still in progress. The renal artery blood flow decreased slightly at low infusion rates and increased at higher. At SP infusions in the portal vein the infusion rate had to be increased to 20 ng × min‐1× kg b.w.‐1 or higher before any general vascular reactions were recorded, indicating that the liver has a high capacity for inactivating SP.

Journal

Acta Physiologica – Wiley

Published: Feb 1, 1975

There are no references for this article.