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- Publisher
- Wiley
- Copyright
- "© 2018 Wiley Periodicals, Inc."
- ISSN
- 1549-3296
- eISSN
- 1552-4965
- DOI
- 10.1002/jbm.a.36400
- Publisher site
- See Article on Publisher Site
Abstract
Nanoparticle shape has emerged as a key regulator of nanoparticle transport across physiological barriers, intracellular uptake, and biodistribution. We report a facile approach to synthesize ellipsoidal nanoparticles through self‐assembly of poly(glycerol sebacate)‐co‐poly(ethylene glycol) (PGS‐co‐PEG). The PGS‐PEG nanoparticle system is highly tunable, and the semiaxis length of the nanoparticles can be modulated by changing PGS‐PEG molar ratio and incorporating therapeutics. As both PGS and PEG are highly biocompatible, the PGS‐co‐PEG nanoparticles show high hemo‐, immuno‐, and cytocompatibility. Our data suggest that PGS‐co‐PEG nanoparticles have the potential for use in a wide range of biomedical applications including regenerative medicine, stem cell engineering, immune modulation, and cancer therapeutics. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2048–2058, 2018.
Journal
Journal of Biomedical Materials Research Part A – Wiley
Published: Jul 1, 2018
Keywords: ; ; ;