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Emerging Concepts in Antibiotic Prophylaxis for Cesarean Delivery A Systematic Review

Emerging Concepts in Antibiotic Prophylaxis for Cesarean Delivery A Systematic Review Review Emerging Concepts in Antibiotic Prophylaxis for Cesarean Delivery A Systematic Review Alan T. N. Tita, MD, PhD, Dwight J. Rouse, MD, MSPH, Sean Blackwell, MD, George R. Saade, MD, Catherine Y. Spong, MD, and William W. Andrews, PhD, MD OBJECTIVE: To review the current status of antibiotic use of extended-spectrum regimens (involving azithro- prophylaxis for cesarean delivery, emerging strategies to mycin or metronidazole) after cord clamp may reduce postcesarean maternal infection by up to 50%. However, enhance the effectiveness of antibiotic prophylaxis in these two strategies have not been compared with each reducing postcesarean infection, and the implications of the emerging practices. other. In addition, their effect on neonatal infection or infection with resistant organisms warrants further study. DATA SOURCES: We conducted a full PubMed (January CONCLUSION: The use of either cefazolin alone before 1966 to July 2008) search using the key words “cesarean” surgical incision or an extended-spectrum regimen after and “antibiotic prophylaxis.” A total of 277 articles were identified and supplemented by a bibliographic search. cord clamp seems to be associated with a reduction in postcesarean maternal infection. Confirmatory studies METHODS OF STUDY SELECTION: We selected a total focusing additionally on neonatal outcomes and the of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Obstetrics & Gynecology Wolters Kluwer Health

Emerging Concepts in Antibiotic Prophylaxis for Cesarean Delivery A Systematic Review

Andrews, William W.
Obstetrics & Gynecology , Volume 113 (3) – Mar 1, 2009
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References (69)

ISSN
0029-7844
eISSN
1873-233X
DOI
10.1097/AOG.0b013e318197c3b6
pmid
19300334
Publisher site
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Abstract

Review Emerging Concepts in Antibiotic Prophylaxis for Cesarean Delivery A Systematic Review Alan T. N. Tita, MD, PhD, Dwight J. Rouse, MD, MSPH, Sean Blackwell, MD, George R. Saade, MD, Catherine Y. Spong, MD, and William W. Andrews, PhD, MD OBJECTIVE: To review the current status of antibiotic use of extended-spectrum regimens (involving azithro- prophylaxis for cesarean delivery, emerging strategies to mycin or metronidazole) after cord clamp may reduce postcesarean maternal infection by up to 50%. However, enhance the effectiveness of antibiotic prophylaxis in these two strategies have not been compared with each reducing postcesarean infection, and the implications of the emerging practices. other. In addition, their effect on neonatal infection or infection with resistant organisms warrants further study. DATA SOURCES: We conducted a full PubMed (January CONCLUSION: The use of either cefazolin alone before 1966 to July 2008) search using the key words “cesarean” surgical incision or an extended-spectrum regimen after and “antibiotic prophylaxis.” A total of 277 articles were identified and supplemented by a bibliographic search. cord clamp seems to be associated with a reduction in postcesarean maternal infection. Confirmatory studies METHODS OF STUDY SELECTION: We selected a total focusing additionally on neonatal outcomes and the of

Journal

Obstetrics & Gynecology – Wolters Kluwer Health

Published: Mar 1, 2009

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