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- Publisher
- Springer Journals
- Copyright
- Copyright © 1993 by Nature Publishing Group
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/361536a0
- Publisher site
- See Article on Publisher Site
Abstract
THE neurotransmitter dopamine acts through various receptor subtypes that are largely associated with enhancement or inhibition of adenylyl cyclases1,2. These dopamine-sensitive adenylyl cyclases are highly concentrated in the corpus striatum and associated limbic structures of the brain, where their levels exceed by orders of magnitude3,4 those in other areas of the brain. Here we use in situ hybridization to show that messenger RNA for three of these adenylyl cyclases5–7 is not found in the corpus striatum. We have isolated and expressed a complementary DNA encoding new adenylyl cyclase whose selective concentration in the corpus striatum indicates that it may be responsible for the synaptic actions of dopamine.
Journal
Nature – Springer Journals
Published: Feb 11, 1993