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The effects of amfonelic acid on 5-HT metabolism in rat brain

The effects of amfonelic acid on 5-HT metabolism in rat brain The non-amphetamine stimulant amfonelic acid (AFA), an inhibitor of dopamine (DA) uptake, has been found to increase the levels of tryptophan (TRYP) and 5-hydroxyindoleacetic acid (5-HIAA) in the rat c. striatum, cerebral cortex, and brain stem. Pretreatment with the DA antagonist haloperidol did not affect this action of AFA in the c. striatum, suggesting that it is independent of the effects of this compound on DA neurons. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Neural Transmission Springer Journals

The effects of amfonelic acid on 5-HT metabolism in rat brain

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References (30)

Publisher
Springer Journals
Copyright
Copyright © 1983 by Springer-Verlag
Subject
Medicine & Public Health; Neurology; Psychiatry; Neurosciences
ISSN
0300-9564
eISSN
1435-1463
DOI
10.1007/BF01245115
Publisher site
See Article on Publisher Site

Abstract

The non-amphetamine stimulant amfonelic acid (AFA), an inhibitor of dopamine (DA) uptake, has been found to increase the levels of tryptophan (TRYP) and 5-hydroxyindoleacetic acid (5-HIAA) in the rat c. striatum, cerebral cortex, and brain stem. Pretreatment with the DA antagonist haloperidol did not affect this action of AFA in the c. striatum, suggesting that it is independent of the effects of this compound on DA neurons.

Journal

Journal of Neural TransmissionSpringer Journals

Published: Feb 16, 2005

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