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Mechanisms of atrial remodeling and clinical relevance

Mechanisms of atrial remodeling and clinical relevance a,b a a,b Stanley Nattel , Akiko Shiroshita-Takeshita , Sophie Cardin and a,c Patricia Pelletier Purpose of review Correspondence to Stanley Nattel, MD, Montreal Heart Institute Research Center, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8 Atrial fibrillation usually occurs in the context of an atrial Tel: 514 376 3330 ext. 3990; fax: 514 376 1355; e-mail: substrate produced by alterations in atrial tissue [email protected] properties referred to as remodeling. Remodeling can Supported by the Canadian Institutes of Health Research, the Quebec Heart result from cardiac disease, cardiac arrhythmias, or Foundation and the Mathematics of Information Technology and Complex Systems (MITACS) Network of Centers of Excellence. biologic processes such as senescence. Recent advances in understanding remodeling have allowed for insights into Current Opinion in Cardiology 2005, 20:21–25 mechanisms underlying atrial fibrillation that have been Abbreviations transferred from experimental models to humans. This paper AF atrial fibrillation reviews recent progress in understanding atrial remodeling, CHF congestive heart failure MMP matrix metalloproteinase as well as the consequent clinical insights into atrial fibrillation pathophysiology and treatment. © 2004 Lippincott Williams & Wilkins 0268-4705 Recent findings Two principal forms of remodeling have been described in animal models of atrial fibrillation: ionic remodeling, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Opinion in Cardiology Wolters Kluwer Health

Mechanisms of atrial remodeling and clinical relevance

Pelletier, Patricia
Current Opinion in Cardiology , Volume 20 (1) – Jan 1, 2005
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References (37)

ISSN
0268-4705
eISSN
1531-7080
DOI
10.1097/01.hco.0000147378.44509.7a
Publisher site
See Article on Publisher Site

Abstract

a,b a a,b Stanley Nattel , Akiko Shiroshita-Takeshita , Sophie Cardin and a,c Patricia Pelletier Purpose of review Correspondence to Stanley Nattel, MD, Montreal Heart Institute Research Center, 5000 Belanger Street East, Montreal, Quebec, Canada H1T 1C8 Atrial fibrillation usually occurs in the context of an atrial Tel: 514 376 3330 ext. 3990; fax: 514 376 1355; e-mail: substrate produced by alterations in atrial tissue [email protected] properties referred to as remodeling. Remodeling can Supported by the Canadian Institutes of Health Research, the Quebec Heart result from cardiac disease, cardiac arrhythmias, or Foundation and the Mathematics of Information Technology and Complex Systems (MITACS) Network of Centers of Excellence. biologic processes such as senescence. Recent advances in understanding remodeling have allowed for insights into Current Opinion in Cardiology 2005, 20:21–25 mechanisms underlying atrial fibrillation that have been Abbreviations transferred from experimental models to humans. This paper AF atrial fibrillation reviews recent progress in understanding atrial remodeling, CHF congestive heart failure MMP matrix metalloproteinase as well as the consequent clinical insights into atrial fibrillation pathophysiology and treatment. © 2004 Lippincott Williams & Wilkins 0268-4705 Recent findings Two principal forms of remodeling have been described in animal models of atrial fibrillation: ionic remodeling,

Journal

Current Opinion in Cardiology – Wolters Kluwer Health

Published: Jan 1, 2005

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