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Johannes Holtfreter's contributions to ongoing studies of the organizer

Johannes Holtfreter's contributions to ongoing studies of the organizer INTRODUCTION The contributions of Johannes Holtfreter to the understanding of the organizer’s role in inductive patterning of the amphibian embryo are so integral to vertebrate developmental biology that it is hard for newcomers to the field to realize that these insights were largely gained by one man in a 26-year period, from 1929-1955. He published approximately 59 research articles and key reviews in this period (Fig. 1). The peak year of 1933 saw 7 publications totaling 372 pages. The gaps in publication represent years of travel and two years of internment as an enemy alien in Canada. All publications are sole-authored except for three: a 1932 paper with Bautzmann, Spemann, and Mangold on inductions by dead organizer tissue (Bautzmann et al., 19321, the Tomes and Holtfreter paper (1955) on tissue affinities, and the 1955 comprehensive review on amphibian development and induction with V. Hamburger, which is still required reading for students of the field (Holtfreter and Hamburger, 1955). A measure of the impact of his work is given by the facts that in a major book on induction, namely, Primary Embryonic Induction by Saxen and Toivonen (1962),30 of his publications are discussed, more than for any other author, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Developmental Dynamics Wiley

Johannes Holtfreter's contributions to ongoing studies of the organizer

Gerhart, J.
Developmental Dynamics , Volume 205 (3) – Mar 1, 1996
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References (85)

Publisher
Wiley
Copyright
Copyright © 1996 Wiley‐Liss, Inc.
ISSN
1058-8388
eISSN
1097-0177
DOI
10.1002/(SICI)1097-0177(199603)205:3<245::AID-AJA5>3.0.CO;2-I
pmid
8850561
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTION The contributions of Johannes Holtfreter to the understanding of the organizer’s role in inductive patterning of the amphibian embryo are so integral to vertebrate developmental biology that it is hard for newcomers to the field to realize that these insights were largely gained by one man in a 26-year period, from 1929-1955. He published approximately 59 research articles and key reviews in this period (Fig. 1). The peak year of 1933 saw 7 publications totaling 372 pages. The gaps in publication represent years of travel and two years of internment as an enemy alien in Canada. All publications are sole-authored except for three: a 1932 paper with Bautzmann, Spemann, and Mangold on inductions by dead organizer tissue (Bautzmann et al., 19321, the Tomes and Holtfreter paper (1955) on tissue affinities, and the 1955 comprehensive review on amphibian development and induction with V. Hamburger, which is still required reading for students of the field (Holtfreter and Hamburger, 1955). A measure of the impact of his work is given by the facts that in a major book on induction, namely, Primary Embryonic Induction by Saxen and Toivonen (1962),30 of his publications are discussed, more than for any other author,

Journal

Developmental Dynamics – Wiley

Published: Mar 1, 1996

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