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References (7)
-
K. Spencer (1991)
Evaluation of an assay of the free beta-subunit of choriogonadotropin and its potential value in screening for Down's syndrome.Clinical chemistry, 37 6
-
J. Macri, R. Kasturi, D. Krantz, E. Cook, N. Moore, Jean Young, K. Romero, J. Larsen (1990)
Maternal serum Down syndrome screening: free beta-protein is a more effective marker than human chorionic gonadotropin.American journal of obstetrics and gynecology, 163 4 Pt 1
-
K. Spencer, J. Macri (1992)
Early Detection of Down's Syndrome Using Free Beta Human ChoriogonadotropinAnnals of Clinical Biochemistry, 29
-
T. Reynolds, M. Penney (1990)
The Mathematical Basis of Multivariate Risk Screening: With Special Reference to Screening for Down's Syndrome Associated PregnancyAnnals of Clinical Biochemistry, 27
-
N. Wald, H. Cuckle, J. Densem, K. Nanchahal, P. Royston, T. Chard, J. Haddow, G. Knight, G. Palomaki, J. Canick (1988)
Maternal serum screening for Down's syndrome in early pregnancy.British Medical Journal, 297
-
(1992)
Serum screening for Down syndrome: a joint report for the Welsh Office, Confidential Report: February -
S. Susini, F. Strigini, A. Puccetti, P. Fioretti (1992)
maternal serum screening for Down, syndrome. preliminary results, 6
- Publisher
- Wiley
- Copyright
- Copyright © 1993 John Wiley & Sons, Ltd.
- ISSN
- 0197-3851
- eISSN
- 1097-0223
- DOI
- 10.1002/pd.1970130617
- Publisher site
- See Article on Publisher Site
Abstract
Free β‐HCG is a new analyte that has been suggested to be superior to total HCG when used in combination with alpha‐fetoprotein (AFP) for Down syndrome risk screening in early pregnancy. We have evaluated this claim on 21 samples collected from Down syndrome pregnancies and 180 samples from unaffected pregnancies. The detection rates for the combination of AFP with free β‐HCG or the combination of AFP with total HCG were identical (71 per cent) but the initial screen positive rate (equivalent to the false‐positive rate) was 7·5 per cent for AFP+free β‐HCG screening compared with 3·5 per cent for AFP+ total HCG screening. We conclude that the case for free β‐HCG is unproven and suggest that further data be collected before free β‐HCG becomes acceptable.
Journal
Prenatal Diagnosis – Wiley
Published: Jun 1, 1993