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- Publisher
- Wiley
- Copyright
- Copyright © 1970 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0008-543X
- eISSN
- 1097-0142
- DOI
- 10.1002/1097-0142(197012)26:6<1186::AID-CNCR2820260603>3.0.CO;2-C
- Publisher site
- See Article on Publisher Site
Abstract
An ultrastructural study of intraductal carcinomas of the breast disclosed profound alterations along the epithelial‐stromal junction of the neoplastic ducts. These alterations included straightening of plasma membranes, dilatation of intercellular spaces, defective basal laminae, inconstant and uneven increase or decrease in collagen and elastic fibers, and disarray of delimiting fibroblasts. The earliest detectable stages of invasion were characterized by neoplastic cytoplasmic protrusions into the stroma through gaps in the basal laminae. Frequently, these invasive foci could not be resolved by the light microscope. These ultrastructural findings, along with previous clinical and histochemical observations, indicate that the histologic diagnosis of “intraductal carcinoma in situ” is currently a hazardous one to make. No clear‐cut causal relationship between invasive process and absence of basal laminae was demonstrated. Possibly as a result of estrogenic stimulation, stromal fibroblasts frequently showed a prominent ergastoplasm, and venules had an unusually large number of endothelial fenestrations.
Journal
Cancer – Wiley
Published: Dec 1, 1970