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References (30)
-
Mariann Blum, Bruce Mcewens, James Roberts (1987)
Transcriptional analysis of tyrosine hydroxylase gene expression in the tuberoinfundibular dopaminergic neurons of the rat arcuate nucleus after estrogen treatment.The Journal of biological chemistry, 262 2
-
Sofía García-Mauriño, David Pozo, A. Carrillo-Vico, Juan Calvo, Juan Guerrero (1999)
Melatonin activates Th1 lymphocytes by increasing IL-12 production.Life sciences, 65 20
-
S. García-Mauriño, D. Pozo, J. Calvo, Josep Guerrero (2000)
Correlation between nuclear melatonin receptor expression and enhanced cytokine production in human lymphocytic and monocytic cell linesJournal of Pineal Research, 29
-
K. Morrey, J. Mclachlan, C. Serkin, O. Bakouche (1994)
Activation of human monocytes by the pineal hormone melatonin.Journal of immunology, 153 6
-
M. Rafii-el-idrissi, J. Calvo, A. Harmouch, S. García-Mauriño, J. Guerrero (1998)
Specific binding of melatonin by purified cell nuclei from spleen and thymus of the ratJournal of Neuroimmunology, 86
-
M. Lopez-Gonzalez, J. Calvo, C. Osuna, Josep Guerrero (1992)
Interaction of melatonin with human lymphocytes: Evidence for binding sites coupled to potentiation of cyclic AMP stimulated by vasoactive intestinal peptide and activation of cyclic GMPJournal of Pineal Research, 12
-
(1997)
Melatonin enhances IL-2, IL-6 and IFN-γ production by human circulating CD4+ cells: a possible nuclear-receptor mediated mechanism involving Th1 lymphocytes and monocytes -
R. Nelson, G. Demas, S. Klein, L. Kriegsfeld (1995)
Minireview The influence of season, photoperiod, and pineal melatonin on immune functionJournal of Pineal Research, 19
-
A. Weiss, R. Wiskocil, J. Stobo (1984)
The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level.Journal of immunology, 133 1
-
(1995)
High-affinity binding of melatonin by human circulating T lym- phocytes (CD4+) -
(1998)
GUER- RERO -
M. Rafii-el-idrissi, J. Calvo, D. Pozo, A. Harmouch, J. Guerrero (1995)
Specific binding of 2-[125I]iodomelatonin by rat splenocytes: characterization and its role on regulation of cyclic AMP productionJournal of Neuroimmunology, 57
-
I. Wiesenberg, M. Missbach, J. Kahlen, M. Schräder, C. Carlberg (1995)
Transcriptional activation of the nuclear receptor RZR alpha by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand.Nucleic acids research, 23 3
-
Antonio García‐Pergañeda, David Pozo, Juan Guerrero, Juan Calvo (1997)
Signal transduction for melatonin in human lymphocytes: involvement of a pertussis toxin-sensitive G protein.Journal of immunology, 159 8
-
P. Depreux, D. Lesieur, H. Mansour, P. Morgan, H. Howell, P. Renard, D. Caignard, B. Pfeiffer, P. Delagrange, B. Guardiola (1998)
Synthesis and structure-activity relationships of novel naphthalenic and bioisosteric related amidic derivatives as melatonin receptor ligands.Journal of medicinal chemistry, 37 20
-
R. Wurtman, J. Axelrod, J. Fischer (1964)
Melatonin Synthesis in the Pineal Gland: Effect of Light Mediated by the Sympathetic Nervous SystemScience, 143
-
R. Reiter (1998)
Melatonin and human reproduction.Annals of medicine, 30 1
-
P. Barrett, G. Davidson, D. Hazlerigg, M. Morris, A. Ross, P. Morgan (1998)
Mel 1a melatonin receptor expression is regulated by protein kinase C and an additional pathway addressed by the protein kinase C inhibitor Ro 31-8220 in ovine pars tuberalis cells.Endocrinology, 139 1
-
J. Guerrero, R. Reiter (1992)
A brief survey of pineal gland-immune system interrelationships.Endocrine research, 18 2
-
Depreux (1994)
Synthesis and structure-activity relationships of novel naphthalenic and bioisosteric related amidic derivatives as melatonin receptor ligandsJ. Med. Chem., 37
-
G. Maestroni (1998)
The photoperiod transducer melatonin and the immune-hematopoietic system.Journal of photochemistry and photobiology. B, Biology, 43 3
-
G. Scatchard (1949)
THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences, 51
-
S. García-Mauriño, Maria Gonzalez‐Haba, J. Calvo, R. Goberna, J. Guerrero (1998)
Involvement of nuclear binding sites for melatonin in the regulation of IL-2 and IL-6 production by human blood mononuclear cellsJournal of Neuroimmunology, 92
-
S. García-Mauriño, Maria Gonzalez‐Haba, J. Calvo, M. Rafii-el-idrissi, V. Sánchez-Margalet, R. Goberna, Josep Guerrero (1997)
Melatonin enhances IL-2, IL-6, and IFN-gamma production by human circulating CD4+ cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes.Journal of immunology, 159 2
-
Maria Gonzalez‐Haba, S. García-Mauriño, J. Calvo, R. Goberna, Josep Guerrero (1995)
High‐affinity binding of melatonin by human circulating T lymphocytes (CD4+)The FASEB Journal, 9
-
R. Reiter (1995)
Oxidative processes and antioxidative defense mechanisms in the aging brain 1The FASEB Journal, 9
-
García-Pergañeda (1997)
Signal transduction for melatonin in human lymphocytesInvolvement of a pertussis toxin-sensitive G protein. J. Immunol., 159
-
Walter Pierpaoli, William Regelson (1994)
Pineal control of aging: effect of melatonin and pineal grafting on aging mice.Proceedings of the National Academy of Sciences of the United States of America, 91
-
M. Barjavel, Zahra Mamdouh, Nadjibe Raghbate, Ouahid Bakouche (1998)
Differential expression of the melatonin receptor in human monocytes.Journal of immunology, 160 3
-
D. Pozo, M. Delgado, J. Fernández-Santos, J. Calvo, R. Gomariz, Inés Martín-Lacave, G. Ortiz, Josep Guerrero (1997)
Expression of the Mel1a‐melatonin receptor mRNA in T and B subsets of lymphocytes from rat thymus and spleenThe FASEB Journal, 11
- Publisher
- Wiley
- Copyright
- Copyright © 2000 Wiley Subscription Services
- ISSN
- 0077-8923
- eISSN
- 1749-6632
- DOI
- 10.1111/j.1749-6632.2000.tb05404.x
- Publisher site
- See Article on Publisher Site
Abstract
Abstract: This report shows that melatonin enhances IL‐2 production by Jurkat cells via a nuclear receptor‐mediated mechanism. Jurkat cells express nuclear (RZRα, RORα1, and RORα2) and membrane (mt1) melatonin receptors, and melatonin binds to Jurkat nuclei and membranes with the same affinity described for human peripheral blood mononuclear cells (PBMCs). Melatonin enhances IL‐2 production by Jurkat cells activated by either phytohemagglutinin (PHA) or phorbol myristate acetate (PMA). PHA activation of Jurkat cells does not change the profile of melatonin receptor expression; on the contrary, PMA activation negatively regulates the mt1 receptor. In the absence of the membrane receptor, melatonin still activates the IL‐2 production. These results show that the expression of the nuclear melatonin receptor is sufficient for melatonin to activate IL‐2 production by Jurkat cells.
Journal
Annals of the New York Academy of Sciences – Wiley
Published: Jan 1, 2000