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The determinants of hospital mortality among patients with septic shock receiving appropriate initial antibiotic treatment*

The determinants of hospital mortality among patients with septic shock receiving appropriate... Jdivya The determinants of hospital mortality among patients with septic shock receiving appropriate initial antibiotic treatment* Andrew Labelle, MD; Paul Juang, PharmD; Richard Reichley, PharmD; Scott Micek, PharmD; Justin Hoffmann; Alex Hoban, BS; Nicholas Hampton, PharmD; Marin Kollef, MD Objective: To identify the determinants of hospital mortality ratio 1.99; 95% confidence interval 1.52–2.60; p = .011) and among patients with septic shock receiving appropriate initial increasing Acute Physiology and Chronic Health Evaluation II antibiotic treatment. scores (one-point increments) (adjusted odds ratio 1.11; 95% con- Design: A retrospective cohort study of hospitalized patients fidence interval 1.09–1.14; p < .001) were independently associ- with blood culture positive septic shock (January 2002–December ated with a greater risk of hospital mortality, whereas infection 2007). with methicillin-susceptible Staphylococcus aureus (adjusted Setting: Barnes-Jewish Hospital, a 1,250-bed urban teaching odds ratio 0.32; 95% confidence interval 0.20–0.52; p = .017) was hospital. independently associated with a lower risk of hospital mortal- Patients: Four hundred thirty-six consecutive patients with ity. Patients infected with methicillin-susceptible Staphylococ- septic shock and a positive blood culture. cus aureus infections were statistically younger and had lower Interventions: Data abstraction from computerized medical Charlson comorbidity and Acute Physiology and Chronic Health records. Evaluation II http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Critical Care Medicine Wolters Kluwer Health

The determinants of hospital mortality among patients with septic shock receiving appropriate initial antibiotic treatment&ast;

Kollef, Marin
Critical Care Medicine , Volume 40 (7) – Jul 1, 2012
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Copyright
Copyright © 2012 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins
ISSN
0090-3493
eISSN
1530-0293
DOI
10.1097/CCM.0b013e318250aa72
pmid
22584765
Publisher site
See Article on Publisher Site

Abstract

Jdivya The determinants of hospital mortality among patients with septic shock receiving appropriate initial antibiotic treatment* Andrew Labelle, MD; Paul Juang, PharmD; Richard Reichley, PharmD; Scott Micek, PharmD; Justin Hoffmann; Alex Hoban, BS; Nicholas Hampton, PharmD; Marin Kollef, MD Objective: To identify the determinants of hospital mortality ratio 1.99; 95% confidence interval 1.52–2.60; p = .011) and among patients with septic shock receiving appropriate initial increasing Acute Physiology and Chronic Health Evaluation II antibiotic treatment. scores (one-point increments) (adjusted odds ratio 1.11; 95% con- Design: A retrospective cohort study of hospitalized patients fidence interval 1.09–1.14; p < .001) were independently associ- with blood culture positive septic shock (January 2002–December ated with a greater risk of hospital mortality, whereas infection 2007). with methicillin-susceptible Staphylococcus aureus (adjusted Setting: Barnes-Jewish Hospital, a 1,250-bed urban teaching odds ratio 0.32; 95% confidence interval 0.20–0.52; p = .017) was hospital. independently associated with a lower risk of hospital mortal- Patients: Four hundred thirty-six consecutive patients with ity. Patients infected with methicillin-susceptible Staphylococ- septic shock and a positive blood culture. cus aureus infections were statistically younger and had lower Interventions: Data abstraction from computerized medical Charlson comorbidity and Acute Physiology and Chronic Health records. Evaluation II

Journal

Critical Care Medicine – Wolters Kluwer Health

Published: Jul 1, 2012

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