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The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

The foreign antigen binding site and T cell recognition regions of class I histocompatibility... Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are clustered on top of the molecule in a large groove identified as the recognition site for processed foreign antigens. Many residues critical for T-cell recognition of HLA are located in this site, in positions allowing them to serve as ligands to processed antigens. These findings have implications for how the products of the major histocompatibility complex (MHC) recognize foreign antigens. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

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References (1)

  • RM Zinkernagel (1974)

    701

    Nature, 248

Publisher
Springer Journals
Copyright
Copyright © 1987 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/329512a0
Publisher site
See Article on Publisher Site

Abstract

Most of the polymorphic amino acids of the class I histocompatibility antigen, HLA-A2, are clustered on top of the molecule in a large groove identified as the recognition site for processed foreign antigens. Many residues critical for T-cell recognition of HLA are located in this site, in positions allowing them to serve as ligands to processed antigens. These findings have implications for how the products of the major histocompatibility complex (MHC) recognize foreign antigens.

Journal

Nature – Springer Journals

Published: Oct 8, 1987

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