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- Publisher
- Springer Journals
- Copyright
- Copyright © 2004 by Springer-Verlag
- Subject
- Medicine
- ISSN
- 0033-3158
- eISSN
- 1432-2072
- DOI
- 10.1007/s00213-003-1673-x
- pmid
- 15205885
- Publisher site
- See Article on Publisher Site
Abstract
Postmortem studies suggest that markers of reduced GABA neurotransmission in schizophrenia may be selective for, or at least particularly prominent in, the subclass of GABA neurons, chandelier cells, that provide inhibitory input to the axon initial segment of populations of pyramidal neurons. Given the critical role that chandelier cells play in synchronizing the activity of pyramidal neurons, the pharmacological amelioration of this deficit may be particularly effective in normalizing the neural network activity required for working memory function. Because GABA A receptors containing the a 2 subunit are selectively localized to the axon initial segment of pyramidal cells, and appear to be markedly up-regulated in schizophrenia, treatment with novel benzodiazepine-like agents with selective activity at GABA A receptors containing the a 2 subunit may be effective adjuvant agents for improving working memory function in schizophrenia.
Journal
Psychopharmacology – Springer Journals
Published: Jun 1, 2004