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Alu elements confer enhancer–promoter specificity

Alu elements confer enhancer–promoter specificity Research highlights Single-cell genomics Plant genomics Human genetics Epigenomics The complex Genomics VNTRs and Alu elements relationship of the oldest disease risk confer enhancer– between cell domesticated promoter specificity transcriptomic wheat Variable numbers of tandem repeats (VNTRs) are a category Enhancers can bypass nearby state and of genomic variants whose genes to communicate with phenotype Einkorn (Triticum monococcum) — contribution to disease risk promoters at long genomic the world’s first domesticated remains underexplored, owing distances, but the underlying wheat species — was domesti- to challenges in genotyping mechanisms are poorly under- Single-cell genomics has been cated approximately 10,000 years VNTRs accurately in large popu- stood. Liang et al. reconstructed used to describe a plethora ago. Ahmed et al. generated lation samples. To overcome enhancer–promoter-derived RNA of novel cellular states on the chromosome-scale genome these challenges, Mukamel et al. interaction (EPRI) maps in six cell basis of their transcriptomic assemblies of a domesticated applied a statistical imputa- lines. Motif scanning analysis on and epigenomic profiles, einkorn landrace, TA10622, and tion approach to estimate the enhancer–promoter sequence but does not in and of itself a wild einkorn accession, TA299. haplotype-resolved repeat junctures showed enrichment identify causal links between The centromeric regions http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Genetics Springer Journals

Alu elements confer enhancer–promoter specificity

Anania, Chiara
Nature Genetics , Volume 55 (9) – Sep 1, 2023
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Alu elements confer enhancer–promoter specificity

Abstract

Research highlights Single-cell genomics Plant genomics Human genetics Epigenomics The complex Genomics VNTRs and Alu elements relationship of the oldest disease risk confer enhancer– between cell domesticated promoter specificity transcriptomic wheat Variable numbers of tandem repeats (VNTRs) are a category Enhancers can bypass nearby state and of genomic variants whose genes to communicate with phenotype Einkorn (Triticum monococcum) — contribution to disease risk promoters at...
 
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Publisher
Springer Journals
Copyright
Copyright © Springer Nature America, Inc. 2023
ISSN
1061-4036
eISSN
1546-1718
DOI
10.1038/s41588-023-01514-8
Publisher site
See Article on Publisher Site

Abstract

Research highlights Single-cell genomics Plant genomics Human genetics Epigenomics The complex Genomics VNTRs and Alu elements relationship of the oldest disease risk confer enhancer– between cell domesticated promoter specificity transcriptomic wheat Variable numbers of tandem repeats (VNTRs) are a category Enhancers can bypass nearby state and of genomic variants whose genes to communicate with phenotype Einkorn (Triticum monococcum) — contribution to disease risk promoters at long genomic the world’s first domesticated remains underexplored, owing distances, but the underlying wheat species — was domesti- to challenges in genotyping mechanisms are poorly under- Single-cell genomics has been cated approximately 10,000 years VNTRs accurately in large popu- stood. Liang et al. reconstructed used to describe a plethora ago. Ahmed et al. generated lation samples. To overcome enhancer–promoter-derived RNA of novel cellular states on the chromosome-scale genome these challenges, Mukamel et al. interaction (EPRI) maps in six cell basis of their transcriptomic assemblies of a domesticated applied a statistical imputa- lines. Motif scanning analysis on and epigenomic profiles, einkorn landrace, TA10622, and tion approach to estimate the enhancer–promoter sequence but does not in and of itself a wild einkorn accession, TA299. haplotype-resolved repeat junctures showed enrichment identify causal links between The centromeric regions

Journal

Nature Genetics – Springer Journals

Published: Sep 1, 2023

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