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Unitary characteristics of presumptive cholinergic tegmental neurons during the sleep-waking cycle in freely moving cats

Unitary characteristics of presumptive cholinergic tegmental neurons during the sleep-waking... 221 76 76 3 3 M. El Mansari K. Sakai M. Jouvet Département de Médecine Expérimentale INSERM U 52, CNRS-UA 1195, Université Claude Bernard 8 Avenue Rockefeller F-69373 Lyon Cedex 08 France Summary A total of 260 neurons were recorded in the rostral pontine tegmentum of freely moving cats during the sleep-waking cycle. Of these, 207 neurons (80%) were located in the dorsal pontine tegmentum containing monoaminergic and choline acetyltransferase (ChAT)-immunoreactive, or cholinergic neurons. In addition to presumably monoaminergic PS-off cells ( n = 51) showing a cessation of discharge during paradoxical sleep (PS) and presumably cholinergic PGO-on cells ( n = 40) exhibiting a burst of discharge just prior to and during ponto-geniculo-occipital (PGO) waves, we observed tonic ( n = 108) and phasic ( n = 61) neurons exhibiting, respectively, tonic and phasic patterns of discharge during wakefulness and/or paradoxical sleep. Of 87 tonic cells histologically localized in the dorsal pontine tegmentum rich in cholinergic neurons, 46 cells (53%) were identified as giving rise to ascending projections either to the intralaminar thalamic complex ( n = 26) or to the ventrolateral posterior hypothalamus ( n = 13) or to both ( n = 9). Two types of tonic neurons were distinguished: 1) tonic type I neurons ( n = 28), showing a tonic pattern and high rates of discharge during both waking and paradoxical sleep as compaired with slow wave sleep; and 2) tonic type II neurons ( n = 20), exhibiting a tonic pattern of discharge highly specific to the periods of paradoxical sleep. Tonic type I neurons were further divided into two subclasses on the basis of discharge rates during waking: a) rapid (Type I-R; n = 17); and b) slow (Type I-S; n = 11) units with a discharge frequency of more than 12 spikes/s or less than 5 spikes/s, respectively. Like monoaminergic PS-off and cholinergic PGO-on cells, both tonic type II and type I-S cells were characterized by a long spike duration (median: 3.3 and 3.5 ms), as well as by a slow conduction velocity (median: 1.8 and 1.7 m/s). In the light of these data, we discuss the possible cholinergic nature and functional significance of these ascending tonic neurons in the generation of neocortical electroencephalographic desynchronization occurring during waking and paradoxical sleep. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Brain Research Springer Journals

Unitary characteristics of presumptive cholinergic tegmental neurons during the sleep-waking cycle in freely moving cats

Mansari, M.; Sakai, K.; Jouvet, M.
Experimental Brain Research , Volume 76 (3) – Aug 1, 1989
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References (63)

Publisher
Springer Journals
Copyright
Copyright © 1989 by Springer-Verlag
Subject
Biomedicine; Neurosciences; Neurology
ISSN
0014-4819
eISSN
1432-1106
DOI
10.1007/BF00248908
Publisher site
See Article on Publisher Site

Abstract

221 76 76 3 3 M. El Mansari K. Sakai M. Jouvet Département de Médecine Expérimentale INSERM U 52, CNRS-UA 1195, Université Claude Bernard 8 Avenue Rockefeller F-69373 Lyon Cedex 08 France Summary A total of 260 neurons were recorded in the rostral pontine tegmentum of freely moving cats during the sleep-waking cycle. Of these, 207 neurons (80%) were located in the dorsal pontine tegmentum containing monoaminergic and choline acetyltransferase (ChAT)-immunoreactive, or cholinergic neurons. In addition to presumably monoaminergic PS-off cells ( n = 51) showing a cessation of discharge during paradoxical sleep (PS) and presumably cholinergic PGO-on cells ( n = 40) exhibiting a burst of discharge just prior to and during ponto-geniculo-occipital (PGO) waves, we observed tonic ( n = 108) and phasic ( n = 61) neurons exhibiting, respectively, tonic and phasic patterns of discharge during wakefulness and/or paradoxical sleep. Of 87 tonic cells histologically localized in the dorsal pontine tegmentum rich in cholinergic neurons, 46 cells (53%) were identified as giving rise to ascending projections either to the intralaminar thalamic complex ( n = 26) or to the ventrolateral posterior hypothalamus ( n = 13) or to both ( n = 9). Two types of tonic neurons were distinguished: 1) tonic type I neurons ( n = 28), showing a tonic pattern and high rates of discharge during both waking and paradoxical sleep as compaired with slow wave sleep; and 2) tonic type II neurons ( n = 20), exhibiting a tonic pattern of discharge highly specific to the periods of paradoxical sleep. Tonic type I neurons were further divided into two subclasses on the basis of discharge rates during waking: a) rapid (Type I-R; n = 17); and b) slow (Type I-S; n = 11) units with a discharge frequency of more than 12 spikes/s or less than 5 spikes/s, respectively. Like monoaminergic PS-off and cholinergic PGO-on cells, both tonic type II and type I-S cells were characterized by a long spike duration (median: 3.3 and 3.5 ms), as well as by a slow conduction velocity (median: 1.8 and 1.7 m/s). In the light of these data, we discuss the possible cholinergic nature and functional significance of these ascending tonic neurons in the generation of neocortical electroencephalographic desynchronization occurring during waking and paradoxical sleep.

Journal

Experimental Brain Research – Springer Journals

Published: Aug 1, 1989

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