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- ISSN
- 0009-7330
- eISSN
- 1524-4571
- DOI
- 10.1161/01.RES.0000251056.85990.db
- pmid
- 17122446
- Publisher site
- See Article on Publisher Site
Abstract
Reviews This Review is part of a thematic series on Transcription Factors, which includes the following articles: Role of Kruppel-Like Transcription Factors in Endothelial Biology Myocardin/MRTFs in Cardiovascular Biology Forkhead Factors in Cardiovascular Biology Notch Signaling and Angiogenesis Mukesh Jain, Guest Editor Regulation of Vascular Inflammation and Remodeling by ETS Factors Peter Oettgen Abstract—The ETS (E26 Transformation-specific Sequence) factors are comprised of a family of transcription factors that share a highly conserved DNA binding domain. Although originally described for their role as protooncogenes in the development of several types of human cancer, they have subsequently been shown to regulate a wide variety of biological processes including cellular growth and differentiation under normal and pathological conditions. As transcription factors, they can either function as activators or repressors of gene expression. Several ETS family members are expressed in cells of vascular origin, including endothelial cells and vascular smooth muscle cells, where they regulate the expression of a number of vascular-specific genes. In the past few years, emerging evidence supports a novel role for selected ETS family members in the regulation of vascular inflammation and remodeling. ETS factor expression can be induced by proinflammatory cytokines, growth factors, and vasoactive peptides. Examples of
Journal
Circulation Research – Wolters Kluwer Health
Published: Nov 1, 2006