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A case of COVID‐19‐associated generalized indeterminate cell histiocytosis successfully treated with systemic PUVA

A case of COVID‐19‐associated generalized indeterminate cell histiocytosis successfully treated... Dear Editor,Histiocytosis is a term used to describe a group of diseases characterized by the proliferation of monocytes, macrophages and dendritic cells. Indeterminate cell histiocytosis (ICH), first described in 1985, is a very rare disease with less than 50 cases reported in the literature.1,2 It usually begins spontaneously, but cases associated with inflammatory triggers such as scabies or pityriasis rosea have been described.3,4We present the case of a 32‐year‐old previously healthy woman who was referred to our clinic with a generalized skin rash of erythematous papulonodules that first manifested during a COVID‐19 infection 6 months ago. After an initial spontaneous resolution of the skin lesions, the patient reported a recent exacerbation (Figure 1a,c). A skin biopsy revealed a dermal infiltrate of histiocytoid cells (Figure 2a,b). Immunostains were predominantly negative for S100 with focal weak staining in isolated cells and strongly positive for CD1a (Figure 2c,d), but negative for langerin (CD207). Mutational analysis revealed no BRAF V600 mutation. Indeterminate cell histiocytosis was diagnosed. Further diagnostics showed no evidence of systemic involvement (complete blood count, lactate dehydrogenase, immunoglobulin panel, whole‐blood flow cytometry and computed tomography of thorax and abdomen). Due to the normal results of the above‐mentioned examinations, bone marrow aspiration was omitted after oncologic http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of the European Academy of Dermatology and Venereology Wiley

A case of COVID‐19‐associated generalized indeterminate cell histiocytosis successfully treated with systemic PUVA

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References (10)

Publisher
Wiley
Copyright
Copyright © 2023 European Academy of Dermatology and Venereology
ISSN
0926-9959
eISSN
1468-3083
DOI
10.1111/jdv.19444
Publisher site
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Abstract

Dear Editor,Histiocytosis is a term used to describe a group of diseases characterized by the proliferation of monocytes, macrophages and dendritic cells. Indeterminate cell histiocytosis (ICH), first described in 1985, is a very rare disease with less than 50 cases reported in the literature.1,2 It usually begins spontaneously, but cases associated with inflammatory triggers such as scabies or pityriasis rosea have been described.3,4We present the case of a 32‐year‐old previously healthy woman who was referred to our clinic with a generalized skin rash of erythematous papulonodules that first manifested during a COVID‐19 infection 6 months ago. After an initial spontaneous resolution of the skin lesions, the patient reported a recent exacerbation (Figure 1a,c). A skin biopsy revealed a dermal infiltrate of histiocytoid cells (Figure 2a,b). Immunostains were predominantly negative for S100 with focal weak staining in isolated cells and strongly positive for CD1a (Figure 2c,d), but negative for langerin (CD207). Mutational analysis revealed no BRAF V600 mutation. Indeterminate cell histiocytosis was diagnosed. Further diagnostics showed no evidence of systemic involvement (complete blood count, lactate dehydrogenase, immunoglobulin panel, whole‐blood flow cytometry and computed tomography of thorax and abdomen). Due to the normal results of the above‐mentioned examinations, bone marrow aspiration was omitted after oncologic

Journal

Journal of the European Academy of Dermatology and Venereology – Wiley

Published: Dec 1, 2023

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