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Signal transduction pathways leading to the production of IL-8 by human monocytes are differentially regulated by dexamethasone

Signal transduction pathways leading to the production of IL-8 by human monocytes are... SUMMARY Previous studies have shown that IL-8 gene expression is enhanced by various stimuli, which induce different signal transduction pathways. A lipopolysaccharide (LPS)-induced pathway has been reported to be inhibited by glucocorticoids in monocytes. We have now examined the effect of dexamethasone on the LPS-induced and other signal transduction pathways leading to the production of IL-8 by human monocytes. Dexamethasone Inhibited the production of IL-8 stimulated with a cyclic adenosine monophosphate analog or LPS. In contrast, dexamethasone had no significant effect on a phorbol ester (PMA)-stimulated IL-8 production. These results suggest that the signal transduction pathways leading to the production of IL-8 by human monocytes are differentially regulated by dexamethasone. glucocorticoids, IL-8, monocytes, signal transduction REFERENCES 1 Schröder , J-M , Mrowietz , U, Morita , E, Christophers , E. Purification and partial characterization of a human monocyte-derived neutrophil-activating peptide that lacks interleukin I activity . J Immunol 1987 ; 139 : 3474 – 83 . Google Scholar PubMed OpenURL Placeholder Text WorldCat 2 Bacon , KB , Westwick , J, Camp , RDR. Potent and specific inhibition of IL-8. IL-1α, and IL-1β -induced in vitro human lymphocyte migration by calcium channel antagonists . Biochem Biophys Res Commun 1989 ; 165 : 349 – 54 . Google Scholar Crossref Search ADS PubMed WorldCat 3 Bazzoni , F , Cassarella , MA, Rossi , F, Ceska , M, Dewaid , B, Baggiolini , M. Phagocytosing neutrophil-activating peptide 1/interleukin 8 . J Exp Med 1991 ; 173 : 771 – 4 . Google Scholar Crossref Search ADS PubMed WorldCat 4 Baggiolini , M , Walz , A, Kunkel , S. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils . J Clin Invest 1989 ; 84 : 1045 – 9 . Google Scholar Crossref Search ADS PubMed WorldCat 5 Mukaida , N , Shiroo , M, Matsushima , K. Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL 8 . J Immunol 1989 ; 143 : 1366 – 71 . Google Scholar PubMed OpenURL Placeholder Text WorldCat 6 Mukaida , N , Mahe , Y, Matsushima , K. Cooperative interaction of nuclear factor-kappaB- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines . J Biol Chem 1990 ; 265 : 21128 – 33 . Google Scholar Crossref Search ADS PubMed WorldCat 7 Geisse , S , Schneidereit , C, Westphal , HM, Hynes , NE, Groner , B, Beato , M. Glucocorticoid receptors recognize DNA sequences in and around murine mammary tumour virus DNA . EMBO J 1982 ; 1 : 1613 – 9 . Google Scholar Crossref Search ADS PubMed WorldCat 8 Jonat , C , Rahmsdorf , HJ, Park , K-K, Cato , ACB, Gebe , S, Ponta , H, Herrlich , P. Antitumor promotion and antiinflammation: downmodulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone Cell 1900 ; 62 : 1189 – 204 . Google Scholar Crossref Search ADS WorldCat 9 Yang-Yen , H-F , Chambard , J-C, Sun , Y-L, Smeal , T, Schmidt , TJ, Drouin , J, Karin , M. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction . Cell 1990 ; 62 : 1205 – 15 . Google Scholar Crossref Search ADS PubMed WorldCat 10 Schule , R , Rangarajan , P, Kliewer , S et al. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor . Cell 1990 ; 62 : 1217 – 26 . Google Scholar Crossref Search ADS PubMed WorldCat 11 Kovacs , EJ , Radzioch , D, Young , HA, Varesio , L. Differential inhibition of IL-1 and TNF-α mRNA expression by agents which block second messenger pathways in murine macrophages . J Immunol 1988 ; 141 : 3101 – 5 . Google Scholar PubMed OpenURL Placeholder Text WorldCat 12 Imagawa , M , Chiu , R, Karin , M. Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP . Cell 1987 ; 51 : 251 – 60 . Google Scholar Crossref Search ADS PubMed WorldCat 13 Ceska , M , Effenberger , F, Peich , P, Purch , E. Purification and characterization of monoclonal and polyclonal antibodies to neutrophil activation peptide (NAP-I). The development of highly sensitive ELISA methods for the determination of NAP-1 and anti-NPA-1 antibodies . Cytokine 1989 ; 1 : 136 (abstr). Google Scholar OpenURL Placeholder Text WorldCat 14 Hurme , M . Modulation of interleukin-1β production by cyclic AMP in human monocytes . FEBS 1990 ; 263 : 35 – 7 . Google Scholar Crossref Search ADS WorldCat 15 Debets , JMH , Ruers , TJM, van der Linden , MPMH, van der Linden , CJ, Buurman , WA. Inhibitory effect of corticosteroids on the secretion of tumour necrosis factor (TNF) by monocytes is dependent on the stimulus inducing TNF synthesis . Clin Exp Immunol 1989 ; 78 : 224 – 9 . Google Scholar PubMed OpenURL Placeholder Text WorldCat 16 Hurme , M , Siljander , P, Anttila , H. Regulation of interleukin-1β production by glucocorticoids in human monocytes: the mechanism of action depends on the activation signal , Biochem Biophys Res Commun 1991 ; 180 : 1383 – 9 . Google Scholar Crossref Search ADS PubMed WorldCat 17 Zhang , Y , Xin-Lin , J, Vilcek , J. Synthesis of interleukin 6 (interferon-β2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cylic AMP . J Biol Chem 1986 ; 263 : 6177 – 82 . Google Scholar Crossref Search ADS WorldCat 18 Knudsen , PJ , Dinarello , CA, Strom , TB. Prostaglandins posttrans-criptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate . J Immunol 1986 ; 137 : 3189 – 94 . Google Scholar PubMed OpenURL Placeholder Text WorldCat 19 Akerblom , IE , Slater , EP, Beato , M, Baxter , JD, Mellon , PL. Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer . Science 1088 ; 241 : 350 – 3 . OpenURL Placeholder Text WorldCat 20 Mrovwictz , U , Sticherling , M, Mielke , V, Schröder , JM, Christophers , E. Neutrophil-activating peptide 1/interleukin 8 mRNA expression and protein secretion by human monocytes: effect of cyclosporin A . Cytokine 1991 ; 3 : 322 – 6 . Google Scholar PubMed OpenURL Placeholder Text WorldCat 21 Leonard , EJ , Yoshimura , T, Tanaka , S, Raffeld , M. Neutrophil recruitment by intradermally injected neutrophil attractant/activation protein-1 . J Invest Dermatol 1991 ; 96 : 690 – 4 . Google Scholar Crossref Search ADS PubMed WorldCat 22 Nickoloff , BJ , Karabin , GD, Barker , JN et al. Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis . Am J Pathol 1991 ; 138 : 129 – 40 . Google Scholar PubMed OpenURL Placeholder Text WorldCat This content is only available as a PDF. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical & Experimental Immunology Oxford University Press

Signal transduction pathways leading to the production of IL-8 by human monocytes are differentially regulated by dexamethasone

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References (51)

Publisher
Oxford University Press
Copyright
Copyright © 2022 British Society for Immunology
ISSN
0009-9104
eISSN
1365-2249
DOI
10.1111/j.1365-2249.1992.tb06990.x
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Abstract

SUMMARY Previous studies have shown that IL-8 gene expression is enhanced by various stimuli, which induce different signal transduction pathways. A lipopolysaccharide (LPS)-induced pathway has been reported to be inhibited by glucocorticoids in monocytes. We have now examined the effect of dexamethasone on the LPS-induced and other signal transduction pathways leading to the production of IL-8 by human monocytes. Dexamethasone Inhibited the production of IL-8 stimulated with a cyclic adenosine monophosphate analog or LPS. In contrast, dexamethasone had no significant effect on a phorbol ester (PMA)-stimulated IL-8 production. These results suggest that the signal transduction pathways leading to the production of IL-8 by human monocytes are differentially regulated by dexamethasone. glucocorticoids, IL-8, monocytes, signal transduction REFERENCES 1 Schröder , J-M , Mrowietz , U, Morita , E, Christophers , E. Purification and partial characterization of a human monocyte-derived neutrophil-activating peptide that lacks interleukin I activity . J Immunol 1987 ; 139 : 3474 – 83 . Google Scholar PubMed OpenURL Placeholder Text WorldCat 2 Bacon , KB , Westwick , J, Camp , RDR. Potent and specific inhibition of IL-8. IL-1α, and IL-1β -induced in vitro human lymphocyte migration by calcium channel antagonists . Biochem Biophys Res Commun 1989 ; 165 : 349 – 54 . Google Scholar Crossref Search ADS PubMed WorldCat 3 Bazzoni , F , Cassarella , MA, Rossi , F, Ceska , M, Dewaid , B, Baggiolini , M. Phagocytosing neutrophil-activating peptide 1/interleukin 8 . J Exp Med 1991 ; 173 : 771 – 4 . Google Scholar Crossref Search ADS PubMed WorldCat 4 Baggiolini , M , Walz , A, Kunkel , S. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils . J Clin Invest 1989 ; 84 : 1045 – 9 . Google Scholar Crossref Search ADS PubMed WorldCat 5 Mukaida , N , Shiroo , M, Matsushima , K. Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL 8 . J Immunol 1989 ; 143 : 1366 – 71 . Google Scholar PubMed OpenURL Placeholder Text WorldCat 6 Mukaida , N , Mahe , Y, Matsushima , K. Cooperative interaction of nuclear factor-kappaB- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines . J Biol Chem 1990 ; 265 : 21128 – 33 . Google Scholar Crossref Search ADS PubMed WorldCat 7 Geisse , S , Schneidereit , C, Westphal , HM, Hynes , NE, Groner , B, Beato , M. Glucocorticoid receptors recognize DNA sequences in and around murine mammary tumour virus DNA . EMBO J 1982 ; 1 : 1613 – 9 . Google Scholar Crossref Search ADS PubMed WorldCat 8 Jonat , C , Rahmsdorf , HJ, Park , K-K, Cato , ACB, Gebe , S, Ponta , H, Herrlich , P. Antitumor promotion and antiinflammation: downmodulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone Cell 1900 ; 62 : 1189 – 204 . Google Scholar Crossref Search ADS WorldCat 9 Yang-Yen , H-F , Chambard , J-C, Sun , Y-L, Smeal , T, Schmidt , TJ, Drouin , J, Karin , M. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction . Cell 1990 ; 62 : 1205 – 15 . Google Scholar Crossref Search ADS PubMed WorldCat 10 Schule , R , Rangarajan , P, Kliewer , S et al. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor . Cell 1990 ; 62 : 1217 – 26 . Google Scholar Crossref Search ADS PubMed WorldCat 11 Kovacs , EJ , Radzioch , D, Young , HA, Varesio , L. Differential inhibition of IL-1 and TNF-α mRNA expression by agents which block second messenger pathways in murine macrophages . J Immunol 1988 ; 141 : 3101 – 5 . Google Scholar PubMed OpenURL Placeholder Text WorldCat 12 Imagawa , M , Chiu , R, Karin , M. Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP . Cell 1987 ; 51 : 251 – 60 . Google Scholar Crossref Search ADS PubMed WorldCat 13 Ceska , M , Effenberger , F, Peich , P, Purch , E. Purification and characterization of monoclonal and polyclonal antibodies to neutrophil activation peptide (NAP-I). The development of highly sensitive ELISA methods for the determination of NAP-1 and anti-NPA-1 antibodies . Cytokine 1989 ; 1 : 136 (abstr). Google Scholar OpenURL Placeholder Text WorldCat 14 Hurme , M . Modulation of interleukin-1β production by cyclic AMP in human monocytes . FEBS 1990 ; 263 : 35 – 7 . Google Scholar Crossref Search ADS WorldCat 15 Debets , JMH , Ruers , TJM, van der Linden , MPMH, van der Linden , CJ, Buurman , WA. Inhibitory effect of corticosteroids on the secretion of tumour necrosis factor (TNF) by monocytes is dependent on the stimulus inducing TNF synthesis . Clin Exp Immunol 1989 ; 78 : 224 – 9 . Google Scholar PubMed OpenURL Placeholder Text WorldCat 16 Hurme , M , Siljander , P, Anttila , H. Regulation of interleukin-1β production by glucocorticoids in human monocytes: the mechanism of action depends on the activation signal , Biochem Biophys Res Commun 1991 ; 180 : 1383 – 9 . Google Scholar Crossref Search ADS PubMed WorldCat 17 Zhang , Y , Xin-Lin , J, Vilcek , J. Synthesis of interleukin 6 (interferon-β2/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cylic AMP . J Biol Chem 1986 ; 263 : 6177 – 82 . Google Scholar Crossref Search ADS WorldCat 18 Knudsen , PJ , Dinarello , CA, Strom , TB. Prostaglandins posttrans-criptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate . J Immunol 1986 ; 137 : 3189 – 94 . Google Scholar PubMed OpenURL Placeholder Text WorldCat 19 Akerblom , IE , Slater , EP, Beato , M, Baxter , JD, Mellon , PL. Negative regulation by glucocorticoids through interference with a cAMP responsive enhancer . Science 1088 ; 241 : 350 – 3 . OpenURL Placeholder Text WorldCat 20 Mrovwictz , U , Sticherling , M, Mielke , V, Schröder , JM, Christophers , E. Neutrophil-activating peptide 1/interleukin 8 mRNA expression and protein secretion by human monocytes: effect of cyclosporin A . Cytokine 1991 ; 3 : 322 – 6 . Google Scholar PubMed OpenURL Placeholder Text WorldCat 21 Leonard , EJ , Yoshimura , T, Tanaka , S, Raffeld , M. Neutrophil recruitment by intradermally injected neutrophil attractant/activation protein-1 . J Invest Dermatol 1991 ; 96 : 690 – 4 . Google Scholar Crossref Search ADS PubMed WorldCat 22 Nickoloff , BJ , Karabin , GD, Barker , JN et al. Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis . Am J Pathol 1991 ; 138 : 129 – 40 . Google Scholar PubMed OpenURL Placeholder Text WorldCat This content is only available as a PDF. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

Journal

Clinical & Experimental Immunology – Oxford University Press

Published: Jun 28, 2008

Keywords: interleukin-8; signal transduction pathways

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