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Dosing of medications in morbidly obese patients in the intensive care unit setting

Dosing of medications in morbidly obese patients in the intensive care unit setting ObjectiveTo derive recommendations for the dosing of commonly used medications in the morbidly obese patient in the ICU.Data sourcesArticles were obtained through computerized searches involving MEDLINE. The bibliographies of retrieved publications and textbooks were reviewed for additional references.Study selectionAll studies involving the pharmacokinetics or pharmacodynamics of medications in obese subjects or patients.Data extractionThe emphasis was on studies involving morbidly obese patients but, in the absence of such data, investigations involving lesser forms of obesity were extracted.Data synthesisThere is a paucity of data upon which to make recommendations for dosing commonly used medications in the morbidly obese patient in the ICU, although recommendations were provided based on the available information.ConclusionsThere is clearly a need for more investigations involving dosing regimens of medications in the morbidly obese population. Until such studies are available, the clinician must try to derive the best dosing regimens for medications based on the limited pharmacokinetic data available for some agents and clinical judgement. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Intensive Care Medicine Springer Journals

Dosing of medications in morbidly obese patients in the intensive care unit setting

Erstad, Brian L.
Intensive Care Medicine , Volume 30 (1) – Jan 1, 2004
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References (98)

Publisher
Springer Journals
Copyright
Copyright © Springer-Verlag 2004
Subject
Medicine & Public Health; Intensive / Critical Care Medicine; Anesthesiology; Emergency Medicine; Pneumology/Respiratory System; Pain Medicine; Pediatrics
ISSN
0342-4642
eISSN
1432-1238
DOI
10.1007/s00134-003-2059-6
pmid
14625670
Publisher site
See Article on Publisher Site

Abstract

ObjectiveTo derive recommendations for the dosing of commonly used medications in the morbidly obese patient in the ICU.Data sourcesArticles were obtained through computerized searches involving MEDLINE. The bibliographies of retrieved publications and textbooks were reviewed for additional references.Study selectionAll studies involving the pharmacokinetics or pharmacodynamics of medications in obese subjects or patients.Data extractionThe emphasis was on studies involving morbidly obese patients but, in the absence of such data, investigations involving lesser forms of obesity were extracted.Data synthesisThere is a paucity of data upon which to make recommendations for dosing commonly used medications in the morbidly obese patient in the ICU, although recommendations were provided based on the available information.ConclusionsThere is clearly a need for more investigations involving dosing regimens of medications in the morbidly obese population. Until such studies are available, the clinician must try to derive the best dosing regimens for medications based on the limited pharmacokinetic data available for some agents and clinical judgement.

Journal

Intensive Care Medicine – Springer Journals

Published: Jan 1, 2004

Keywords: Morbid obesity; Dosing; Pharmacokinetics; Intensive care

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