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How to optimize the effect of 5-fluorouracil modulated therapy in advanced colorectal cancer

How to optimize the effect of 5-fluorouracil modulated therapy in advanced colorectal cancer MEDICAL ONCOLOGY (1995) 12, 187-201 How to optimize the effect of 5-fluorouracil modulated therapy in advanced colorectal cancer PETER RAGNHAMMAR* and HENRIC BLOMGREN Department of Oncology (Radiumhemmet), Karotinska Hospital, S-171 76 Stockholm, Sweden Keywords: 5-fluorouracil; colorectal carcinoma mented, or modulated; by other agents which INTRODUCTION exhibit little if any antitumor activity by them- selves. This rapidly progressive research field is Colorectal adenocarcinoma is one of the most important since it may yield meaningful che- common tumor types in the industrialized western motherapy schedules for patients with advanced countries. At the time of diagnosis, approximately colorectal cancer. More importantly, such sche- 20% of the patients display clinically detectable dules may be used also in adjuvant settings to spread of the disease to distant sites and 40% to prevent relapses following surgery in high risk locoregional lymph nodes [1]. More than half of cases for primary disease. In fact, there are already the patients who undergo surgical procedures some reports showing that 5-FU based modulated with the intent to cure eventually relapse and die chemotherapy may palliate and prolong life of from their disease [21. Radiation therapy may patients with advanced colorectal cancer I9,10], significantly diminish the local recurrence rate, decrease http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Medical Oncology Springer Journals

How to optimize the effect of 5-fluorouracil modulated therapy in advanced colorectal cancer

Ragnhammar, Peter; Blomgren, Henric
Medical Oncology , Volume 12 (3) – Sep 1, 1995
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References (130)

Publisher
Springer Journals
Copyright
Copyright © Humana Press Inc. 1995
ISSN
1357-0560
eISSN
1559-131X
DOI
10.1007/bf01571196
Publisher site
See Article on Publisher Site

Abstract

MEDICAL ONCOLOGY (1995) 12, 187-201 How to optimize the effect of 5-fluorouracil modulated therapy in advanced colorectal cancer PETER RAGNHAMMAR* and HENRIC BLOMGREN Department of Oncology (Radiumhemmet), Karotinska Hospital, S-171 76 Stockholm, Sweden Keywords: 5-fluorouracil; colorectal carcinoma mented, or modulated; by other agents which INTRODUCTION exhibit little if any antitumor activity by them- selves. This rapidly progressive research field is Colorectal adenocarcinoma is one of the most important since it may yield meaningful che- common tumor types in the industrialized western motherapy schedules for patients with advanced countries. At the time of diagnosis, approximately colorectal cancer. More importantly, such sche- 20% of the patients display clinically detectable dules may be used also in adjuvant settings to spread of the disease to distant sites and 40% to prevent relapses following surgery in high risk locoregional lymph nodes [1]. More than half of cases for primary disease. In fact, there are already the patients who undergo surgical procedures some reports showing that 5-FU based modulated with the intent to cure eventually relapse and die chemotherapy may palliate and prolong life of from their disease [21. Radiation therapy may patients with advanced colorectal cancer I9,10], significantly diminish the local recurrence rate, decrease

Journal

Medical Oncology – Springer Journals

Published: Sep 1, 1995

Keywords: 5-fluorouracil; colorectal carcinoma

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