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- Publisher
- Springer Journals
- Copyright
- Copyright © Macmillan Publishers Limited. All rights reserved 2009
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/nature08512
- Publisher site
- See Article on Publisher Site
Abstract
HMGB protein sentinelsThe chromosomal HMGB (high-mobility group box) proteins HMGB1, HMGB2 and HMGB3 are shown here to be essential for all nucleic-acid receptor-mediated activation of innate immune responses. HMGBs bound to all immunogenic nucleic acids tested — whether considered ligands for Toll-like receptors or for cytosolic receptors — suggesting that they may have a physiological role as universal sentinels for intracellular nucleic acids.
Journal
Nature – Springer Journals
Published: Nov 5, 2009