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Role of splenectomy in the management of hemophilic patients with human immunodeficiency virus‐associated immunopathic thrombocytopenic purpura

Role of splenectomy in the management of hemophilic patients with human immunodeficiency... Immunopathic thrombocytopenic purpura (ITP) can be a life‐threatening complication of human immunodeficiency virus (HIV) infection in patients with hemophilia and can seriously compromise quality of life if not managed effectively. We report here complete response to splenectomy in four severe hemophiliacs with HIV‐associated ITP. All patients were symptomatic, had platelet counts less than 25,000/mm3, and had failed at least one non‐surgical therapy prior to splenectomy. All patients tolerated surgery well and obtained an immediate and durable complete response. In addition to our experience, a review of the literature shows that splenectomy is well tolerated and provides the most effective long‐term solution for hemophiliacs with HIV‐ITP. © 1992 Wiley‐Liss, Inc. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Hematology Wiley

Role of splenectomy in the management of hemophilic patients with human immunodeficiency virus‐associated immunopathic thrombocytopenic purpura

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References (26)

Publisher
Wiley
Copyright
Copyright © 1992 Wiley‐Liss, Inc., A Wiley Company
ISSN
0361-8609
eISSN
1096-8652
DOI
10.1002/ajh.2830400309
Publisher site
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Abstract

Immunopathic thrombocytopenic purpura (ITP) can be a life‐threatening complication of human immunodeficiency virus (HIV) infection in patients with hemophilia and can seriously compromise quality of life if not managed effectively. We report here complete response to splenectomy in four severe hemophiliacs with HIV‐associated ITP. All patients were symptomatic, had platelet counts less than 25,000/mm3, and had failed at least one non‐surgical therapy prior to splenectomy. All patients tolerated surgery well and obtained an immediate and durable complete response. In addition to our experience, a review of the literature shows that splenectomy is well tolerated and provides the most effective long‐term solution for hemophiliacs with HIV‐ITP. © 1992 Wiley‐Liss, Inc.

Journal

American Journal of Hematology – Wiley

Published: Jul 1, 1992

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