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- Publisher
- American Medical Association
- Copyright
- Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
- ISSN
- 2168-622X
- eISSN
- 2168-6238
- DOI
- 10.1001/archgenpsychiatry.2007.48
- pmid
- 18316676
- Publisher site
- See Article on Publisher Site
Abstract
ORIGINAL ARTICLE Influence of RGS2 on Anxiety-Related Temperament, Personality, and Brain Function Jordan W. Smoller, MD, ScD; Martin P. Paulus, MD; Jesen A. Fagerness, BA; Shaun Purcell, PhD; Lesley H. Yamaki, BS; Dina Hirshfeld-Becker, PhD; Joseph Biederman, MD; Jerrold F. Rosenbaum, MD; Joel Gelernter, MD; Murray B. Stein, MD, MPH Context: Although anxiety disorders are heritable, their Main Outcome Measures: Laboratory-based behav- genetic and phenotypic complexity has made the iden- ioral measures of childhood temperament, self-report mea- tification of susceptibility genes difficult. Well- sure of personality, and functional magnetic resonance validated animal models and intermediate phenotypes pro- imaging response to emotion processing. vide crucial tools for genetic dissection of anxiety. The gene encoding regulator of G protein signaling 2 (Rgs2) Results: Markers spanning RGS2 were associated with is a quantitative trait gene that influences mouse anxi- childhood behavioral inhibition, a temperamental precur- −5 ety behavior, making its human ortholog (RGS2) a com- sor of social anxiety disorder (haplotype P=3 10 ; odds pelling candidate gene for human anxiety phenotypes. ratio, 2.99 in complete trios). In independent samples, RGS2 markers, including rs4606, which has previously been as- Objective: To examine whether variation in RGS2 is as- sociated with RGS2 expression,
Journal
JAMA Psychiatry – American Medical Association
Published: Mar 1, 2008