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The cell surface receptors for interleukin-1α and interleukin-1β are identical

The cell surface receptors for interleukin-1α and interleukin-1β are identical Interleukin-1 (IL-1) is a factor that can induce proliferation of murine T lymphocytes1,2 and can elicit a variety of other biological responses. These include bone resorption3, fibroblast proliferation4, acute phase protein release from hepatocytes5, cartilage breakdown6 and fever7. This spectrum of activities is consistent with a role for IL-1 as a mediator of inflammation. Recently, sequence data have shown that there are at least two members of the IL-1 family; these distantly related proteins have been termed IL-1α and IL-1β 8–11. We have found previously that both murine T cells and fibroblasts possess a relative molecular mass (M r) ∼80,000 (80K) plasma membrane receptor for human IL-1β 12,13. We show here that the receptor for IL-1α on both murine and human cells is identical to that for IL-1β. This result raises the issue of what separation, if any, there might be between the biological activities of IL-1α and IL-1β. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

The cell surface receptors for interleukin-1α and interleukin-1β are identical

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References (19)

Publisher
Springer Journals
Copyright
Copyright © 1986 by Nature Publishing Group
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/324266a0
Publisher site
See Article on Publisher Site

Abstract

Interleukin-1 (IL-1) is a factor that can induce proliferation of murine T lymphocytes1,2 and can elicit a variety of other biological responses. These include bone resorption3, fibroblast proliferation4, acute phase protein release from hepatocytes5, cartilage breakdown6 and fever7. This spectrum of activities is consistent with a role for IL-1 as a mediator of inflammation. Recently, sequence data have shown that there are at least two members of the IL-1 family; these distantly related proteins have been termed IL-1α and IL-1β 8–11. We have found previously that both murine T cells and fibroblasts possess a relative molecular mass (M r) ∼80,000 (80K) plasma membrane receptor for human IL-1β 12,13. We show here that the receptor for IL-1α on both murine and human cells is identical to that for IL-1β. This result raises the issue of what separation, if any, there might be between the biological activities of IL-1α and IL-1β.

Journal

Nature – Springer Journals

Published: Nov 20, 1986

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