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Prevalence and pathophysiological mechanisms of elevated cardiac troponin I levels in a population-based sample of elderly subjects

Prevalence and pathophysiological mechanisms of elevated cardiac troponin I levels in a... AimsTo evaluate the prevalence of cardiac troponin I (cTnI) elevation in an elderly community population and the association of cTnI levels with cardiovascular risk factors, vascular inflammation, atherosclerosis, cardiac performance, and areas indicative of infarcted myocardium identified by cardiac magnetic resonance imaging.Methods and resultscTnI elevation defined as cTnI levels >0.01 g/L (Access AccuTnI, Beckman Coulter) was found in 21.8 of the study participants (n 1005). cTnI > 0.01 g/L was associated with cardiovascular high-risk features, the burden of atherosclerosis in the carotid arteries, left-ventricular mass, and impaired left-ventricular systolic function. No associations were found between cTnI and inflammatory activity, diastolic dysfunction, or myocardial scars. Male gender (OR 1.6; 95 CI 1.12.4), ischaemic ECG changes (OR 1.7; 95 CI 1.12.7), and NT-pro-brain natriuretic peptide levels (OR 1.4; 95 CI 1.11.7) independently predicted cTnI > 0.01 g/L. cTnI > 0.01 g/L correlated also to an increased cardiovascular risk according to the Framingham risk score.ConclusioncTnI > 0.01 g/L is relatively common in elderly subjects and is associated with cardiovascular high-risk features and impaired cardiac performance. Cardiac troponin determined by a highly sensitive assay might thus serve as an instrument for the identification of subjects at high cardiovascular risk in general populations. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Heart Journal Oxford University Press

Prevalence and pathophysiological mechanisms of elevated cardiac troponin I levels in a population-based sample of elderly subjects

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References (35)

Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
Subject
CLINICAL RESEARCH
ISSN
0195-668X
eISSN
1522-9645
DOI
10.1093/eurheartj/ehn327
pmid
18606612
Publisher site
See Article on Publisher Site

Abstract

AimsTo evaluate the prevalence of cardiac troponin I (cTnI) elevation in an elderly community population and the association of cTnI levels with cardiovascular risk factors, vascular inflammation, atherosclerosis, cardiac performance, and areas indicative of infarcted myocardium identified by cardiac magnetic resonance imaging.Methods and resultscTnI elevation defined as cTnI levels >0.01 g/L (Access AccuTnI, Beckman Coulter) was found in 21.8 of the study participants (n 1005). cTnI > 0.01 g/L was associated with cardiovascular high-risk features, the burden of atherosclerosis in the carotid arteries, left-ventricular mass, and impaired left-ventricular systolic function. No associations were found between cTnI and inflammatory activity, diastolic dysfunction, or myocardial scars. Male gender (OR 1.6; 95 CI 1.12.4), ischaemic ECG changes (OR 1.7; 95 CI 1.12.7), and NT-pro-brain natriuretic peptide levels (OR 1.4; 95 CI 1.11.7) independently predicted cTnI > 0.01 g/L. cTnI > 0.01 g/L correlated also to an increased cardiovascular risk according to the Framingham risk score.ConclusioncTnI > 0.01 g/L is relatively common in elderly subjects and is associated with cardiovascular high-risk features and impaired cardiac performance. Cardiac troponin determined by a highly sensitive assay might thus serve as an instrument for the identification of subjects at high cardiovascular risk in general populations.

Journal

European Heart Journal – Oxford University Press

Published: Sep 7, 2008

Keywords: Keywords Cardiac troponin Cardiovascular disease Risk prediction

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