Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

The role of the anteroventral 3rd ventricle area in the osmotic control of paraventricular neurosecretory cells

The role of the anteroventral 3rd ventricle area in the osmotic control of paraventricular... 221 76 76 3 3 K. Honda H. Negoro T. Higuchi Y. Tadokoro Department of Physiology Fukui Medical School Matsuoka 910-11 Fukui Japan Summary To obtain electrophysiological evidence of an involvement of the anteroventral 3rd ventricle (AV3V) area in the osmotic control of neurohypophysial hormone release, extracellular action potentials of paraventricular (PVN) oxytocinergic and vasopressinergic cells during osmotic stimulation induced by i.p. injection of 1.5 M-NaCl solution were obtained from urethane anesthetized AV3V-lesioned, intact and sham-lesioned lactating rats. In intact and sham-lesioned rats the electrical activities of both oxytocinergic and vasopressinergic cells increased in response to the i.p. injection of hypertonic saline. After electrolytic lesion of the AV3V, the responsiveness of both types of cells to osmotic stimuli was severely impaired, whereas oxytocinergic cells were still capable of responding to suckling stimuli by displaying high frequency discharges of action potentials preceding milk-ejection. These results provide electrophysiological evidence that destruction of the AV3V area selectively impairs osmoregulatory input to PVN neurones and that the area has osmosensitive elements which activate the PVN neurosecretory cells when plasma osmotic pressure rises. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Brain Research Springer Journals

The role of the anteroventral 3rd ventricle area in the osmotic control of paraventricular neurosecretory cells

Download PDF
6 pages

Loading next page...
 
/lp/springer-journals/the-role-of-the-anteroventral-3rd-ventricle-area-in-the-osmotic-FWh3KTFPuO

References (27)

Publisher
Springer Journals
Copyright
Copyright © 1989 by Springer-Verlag
Subject
Biomedicine; Neurosciences; Neurology
ISSN
0014-4819
eISSN
1432-1106
DOI
10.1007/BF00248905
Publisher site
See Article on Publisher Site

Abstract

221 76 76 3 3 K. Honda H. Negoro T. Higuchi Y. Tadokoro Department of Physiology Fukui Medical School Matsuoka 910-11 Fukui Japan Summary To obtain electrophysiological evidence of an involvement of the anteroventral 3rd ventricle (AV3V) area in the osmotic control of neurohypophysial hormone release, extracellular action potentials of paraventricular (PVN) oxytocinergic and vasopressinergic cells during osmotic stimulation induced by i.p. injection of 1.5 M-NaCl solution were obtained from urethane anesthetized AV3V-lesioned, intact and sham-lesioned lactating rats. In intact and sham-lesioned rats the electrical activities of both oxytocinergic and vasopressinergic cells increased in response to the i.p. injection of hypertonic saline. After electrolytic lesion of the AV3V, the responsiveness of both types of cells to osmotic stimuli was severely impaired, whereas oxytocinergic cells were still capable of responding to suckling stimuli by displaying high frequency discharges of action potentials preceding milk-ejection. These results provide electrophysiological evidence that destruction of the AV3V area selectively impairs osmoregulatory input to PVN neurones and that the area has osmosensitive elements which activate the PVN neurosecretory cells when plasma osmotic pressure rises.

Journal

Experimental Brain Research – Springer Journals

Published: Aug 1, 1989

There are no references for this article.