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- Publisher
- Wiley
- Copyright
- Copyright © 1998 Wiley Subscription Services
- ISSN
- 0044-8249
- eISSN
- 1521-3757
- DOI
- 10.1002/(SICI)1521-3757(19981002)110:19<2821::AID-ANGE2821>3.0.CO;2-G
- Publisher site
- See Article on Publisher Site
Abstract
Die Stabilisierung des Übergangszustands durch eine günstige Wechselwirkung zwischen der Doppelbindung von 1 und der Carbonylgruppe von 2 scheint der Grund für die hohe diastereofaciale Selektivität der Aldolreaktion zu sein. Auf diesen Schlüsselschritt der neuen, effizienten Totalsynthese von Epothilon B folgt eine Suzuki‐Kupplung zur Einführung der Thiazoleinheit, eine Noyori‐Reduktion unter Kontrolle der Konfiguration an C3 sowie eine abschließende Makrolactonisierung (siehe Schema). X=Schutzgruppe.
Journal
Angewandte Chemie – Wiley
Published: Jan 2, 1998
Keywords: ; ; ; ;