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Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance

Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive... Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance a b c d Christina M. Marra , Yu Zhao , David B. Clifford , Scott Letendre , b e f g Scott Evans , Katherine Henry , Ronald J. Ellis , Benigno Rodriguez , h i j Robert W. Coombs , Giovanni Schifitto , Justin C. McArthur , Kevin Robertson , for the AIDS Clinical Trials Group 736 Study Team Objective: To determine whether antiretroviral regimens with good central nervous system (CNS) penetration control HIV in cerebrospinal fluid (CSF) and improve cogni- tion. Design: Multisite longitudinal observational study. Setting: Research clinics. Study participants: One hundred and one individuals with advanced HIV beginning or changing a new potent antiretroviral regimen were enrolled in the study. Data for 79 participants were analyzed. Participants underwent structured history and neuro- logical examination, venipuncture, lumbar puncture, and neuropsychological tests at entry, 24, and 52 weeks. Intervention: Antiretroviral regimens were categorized as CNS penetration effective- ness (CPE) rank of at least 2 or less than 2. Generalized estimating equations were used to examine associations over the course of the study. Main outcome measures: Concentration of HIV RNA in CSF and blood http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AIDS Wolters Kluwer Health

Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance

Robertson, Kevin
AIDS , Volume 23 (11) – Jul 1, 2009
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ISSN
0269-9370
eISSN
1473-5571
DOI
10.1097/QAD.0b013e32832c4152
pmid
19424052
Publisher site
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Abstract

Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance a b c d Christina M. Marra , Yu Zhao , David B. Clifford , Scott Letendre , b e f g Scott Evans , Katherine Henry , Ronald J. Ellis , Benigno Rodriguez , h i j Robert W. Coombs , Giovanni Schifitto , Justin C. McArthur , Kevin Robertson , for the AIDS Clinical Trials Group 736 Study Team Objective: To determine whether antiretroviral regimens with good central nervous system (CNS) penetration control HIV in cerebrospinal fluid (CSF) and improve cogni- tion. Design: Multisite longitudinal observational study. Setting: Research clinics. Study participants: One hundred and one individuals with advanced HIV beginning or changing a new potent antiretroviral regimen were enrolled in the study. Data for 79 participants were analyzed. Participants underwent structured history and neuro- logical examination, venipuncture, lumbar puncture, and neuropsychological tests at entry, 24, and 52 weeks. Intervention: Antiretroviral regimens were categorized as CNS penetration effective- ness (CPE) rank of at least 2 or less than 2. Generalized estimating equations were used to examine associations over the course of the study. Main outcome measures: Concentration of HIV RNA in CSF and blood

Journal

AIDS – Wolters Kluwer Health

Published: Jul 1, 2009

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