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Association Between Human Fetuin-A and the Metabolic Syndrome Data From the Heart and Soul Study

Association Between Human Fetuin-A and the Metabolic Syndrome Data From the Heart and Soul Study Association Between Human Fetuin-A and the Metabolic Syndrome Data From the Heart and Soul Study Joachim H. Ix, MD; Michael G. Shlipak, MD, MPH; Vincent M. Brandenburg, MD; Sadia Ali, MD, MPH; Markus Ketteler, MD; Mary A. Whooley, MD Background—Fetuin-A is a multifunctional hepatic secretory protein that inhibits the action of insulin in experimental animals. We evaluated the association between human serum fetuin-A and the metabolic syndrome (MetS) in a cohort of persons with coronary artery disease. Methods and Results—We defined MetS by the National Cholesterol Education Program criteria among 711 nondiabetic outpatients with coronary artery disease. The mean age was 67 years, and 82% were male. We divided participants into quartiles by serum fetuin-A concentrations. A total of 45% of participants (80 of 177) in the highest quartile of fetuin-A had MetS compared with 24% of participants (42 of 177) in the lowest quartile (odds ratio, 2.7; 95% confidence interval, 1.7 to 4.2; P0.001). This association persisted after adjustment for potential confounding variables, including hypertension, body mass index, and inflammatory biomarkers (adjusted odds ratio, 2.0; 95% confidence interval, 1.1 to 3.5; P0.02). Higher fetuin-A quartiles were also strongly and independently associated with higher low-density lipoprotein, non–high-density lipoprotein (HDL), http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Circulation Wolters Kluwer Health

Association Between Human Fetuin-A and the Metabolic Syndrome Data From the Heart and Soul Study

Whooley, Mary A.
Circulation , Volume 113 (14) – Apr 1, 2006
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ISSN
0009-7322
eISSN
1524-4539
DOI
10.1161/CIRCULATIONAHA.105.588723
pmid
16567568
Publisher site
See Article on Publisher Site

Abstract

Association Between Human Fetuin-A and the Metabolic Syndrome Data From the Heart and Soul Study Joachim H. Ix, MD; Michael G. Shlipak, MD, MPH; Vincent M. Brandenburg, MD; Sadia Ali, MD, MPH; Markus Ketteler, MD; Mary A. Whooley, MD Background—Fetuin-A is a multifunctional hepatic secretory protein that inhibits the action of insulin in experimental animals. We evaluated the association between human serum fetuin-A and the metabolic syndrome (MetS) in a cohort of persons with coronary artery disease. Methods and Results—We defined MetS by the National Cholesterol Education Program criteria among 711 nondiabetic outpatients with coronary artery disease. The mean age was 67 years, and 82% were male. We divided participants into quartiles by serum fetuin-A concentrations. A total of 45% of participants (80 of 177) in the highest quartile of fetuin-A had MetS compared with 24% of participants (42 of 177) in the lowest quartile (odds ratio, 2.7; 95% confidence interval, 1.7 to 4.2; P0.001). This association persisted after adjustment for potential confounding variables, including hypertension, body mass index, and inflammatory biomarkers (adjusted odds ratio, 2.0; 95% confidence interval, 1.1 to 3.5; P0.02). Higher fetuin-A quartiles were also strongly and independently associated with higher low-density lipoprotein, non–high-density lipoprotein (HDL),

Journal

Circulation – Wolters Kluwer Health

Published: Apr 1, 2006

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