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Lectins: Their Multiple Endogenous Cellular Functions

Lectins: Their Multiple Endogenous Cellular Functions PERSPECTIVES AND SUMMARY Lectins are divalent or multivalent carbohydrate-binding proteins that are grouped together because they agglutinate cells or other materials that display more than one saccharide of sufficient complementarity. They were discovered in plants, but are also found in all other categories of living 'The US Government has the right to retain a non-exclusive royalty-free license in and to any copyright covering this paper. lThis research was supported by grants from the McKnight Foundation, the US Public Health Service, and the Veterans Administration Medical Center. BARONDES things. To more sharply define this category it has recently been proposed that a number of related proteins be excluded ( l). Among these are monova­ lent carbohydrate-binding toxins such as ricin (because of their valence); carbohydrate-binding immunoglobulins (presumably because they can be included in another structural and functional category); and carbohydrate­ binding enzymes (because they are generally not agglutinins). Polyvalent enzymes such as a glycosidase (2) that can agglutinate cells under certain conditions are considered to "act as a lectin" (1), which reflects a conflict between strictly operational and functional considerations. Failure to emphasize function as a defining characteristic is due to the fact that the endogenous roles of lectins http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Biochemistry Annual Reviews

Lectins: Their Multiple Endogenous Cellular Functions

Barondes, S H
Annual Review of Biochemistry , Volume 50 (1) – Jul 1, 1981
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Publisher
Annual Reviews
Copyright
Copyright 1981 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4154
eISSN
1545-4509
DOI
10.1146/annurev.bi.50.070181.001231
pmid
7023359
Publisher site
See Article on Publisher Site

Abstract

PERSPECTIVES AND SUMMARY Lectins are divalent or multivalent carbohydrate-binding proteins that are grouped together because they agglutinate cells or other materials that display more than one saccharide of sufficient complementarity. They were discovered in plants, but are also found in all other categories of living 'The US Government has the right to retain a non-exclusive royalty-free license in and to any copyright covering this paper. lThis research was supported by grants from the McKnight Foundation, the US Public Health Service, and the Veterans Administration Medical Center. BARONDES things. To more sharply define this category it has recently been proposed that a number of related proteins be excluded ( l). Among these are monova­ lent carbohydrate-binding toxins such as ricin (because of their valence); carbohydrate-binding immunoglobulins (presumably because they can be included in another structural and functional category); and carbohydrate­ binding enzymes (because they are generally not agglutinins). Polyvalent enzymes such as a glycosidase (2) that can agglutinate cells under certain conditions are considered to "act as a lectin" (1), which reflects a conflict between strictly operational and functional considerations. Failure to emphasize function as a defining characteristic is due to the fact that the endogenous roles of lectins

Journal

Annual Review of Biochemistry – Annual Reviews

Published: Jul 1, 1981

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