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References (31)
-
R. Marchioli, M. Franzosi, E. Geraci (1999)
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico.The Lancet
-
Chia Nan, I. Fierro, K. Gronert, C. Serhan (2000)
Activation of Lipoxin a4 Receptors by Aspirin-Triggered Lipoxins and Select Peptides Evokes Ligand-Specific Responses in InflammationThe Journal of Experimental Medicine, 191
-
P. Tessier, P. Naccache, I. Clark‐Lewis, R. Gladue, K. Neote, S. McColl (1997)
Involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-α -
Yan Cheng, S. Austin, B. Rocca, B. Koller, T. Coffman, T. Grosser, J. Lawson, G. FitzGerald (2002)
Role of Prostacyclin in the Cardiovascular Response to Thromboxane A2Science, 296
-
J. Aliberti, S. Hieny, C. Sousa, C. Serhan, A. Sher (2002)
Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunityNature Immunology, 3
-
A. Gewirtz, L. Collier-Hyams, A. Young, T. Kucharzik, W. Guilford, J. Parkinson, I. Williams, A. Neish, J. Madara (2002)
Lipoxin A4 Analogs Attenuate Induction of Intestinal Epithelial Proinflammatory Gene Expression and Reduce the Severity of Dextran Sodium Sulfate-Induced Colitis1The Journal of Immunology, 168
-
P. Tessier, P. Naccache, Ian Clark-Lewis, R. Gladue, K. Neote, S. McColl (1997)
Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha.Journal of immunology, 159 7
-
M. Perretti (2003)
The annexin 1 receptor(s): is the plot unravelling?Trends in pharmacological sciences, 24 11
-
V. Wittamer, J. Franssen, M. Vulcano, J. Mirjolet, E. Poul, I. Migeotte, S. Brézillon, R. Tyldesley, C. Blanpain, M. Detheux, A. Mantovani, S. Sozzani, G. Vassart, M. Parmentier, D. Communi (2003)
Specific Recruitment of Antigen-presenting Cells by Chemerin, a Novel Processed Ligand from Human Inflammatory FluidsThe Journal of Experimental Medicine, 198
-
M. Samson, A. Edinger, P. Stordeur, J. Rucker, V. Verhasselt, M. Sharron, C. Govaerts, C. Mollereau, G. Vassart, R. Doms, M. Parmentier (1998)
ChemR23, a putative chemoattractant receptor, is expressed in monocyte‐derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV‐1 strainsEuropean Journal of Immunology, 28
-
E. Kopp, S. Ghosh (1994)
Inhibition of NF-kappa B by sodium salicylate and aspirin.Science, 265 5174
-
protocol. Primers used in amplifications were as follows: human ChemR23 -
S. Foley, S. Buhre, Dorrit Jacob (2003)
Evolution of the Archaean crust by delamination and shallow subductionNature, 421
-
C. Serhan, Song Hong, K. Gronert, S. Colgan, P. Devchand, Gudrun Mirick, Rose-Laure Moussignac (2002)
Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals.The Journal of experimental medicine, 196 8
-
C. Clish, J. O’Brien, K. Gronert, G. Stahl, N. Petasis, C. Serhan (1999)
Local and systemic delivery of a stable aspirin-triggered lipoxin prevents neutrophil recruitment in vivo.Proceedings of the National Academy of Sciences of the United States of America, 96 14
-
Karsten Gronert, Sean Colgan, Charles Serhan (1998)
Characterization of human neutrophil and endothelial cell ligand-operated extracellular acidification rate by microphysiometry: impact of reoxygenation.The Journal of pharmacology and experimental therapeutics, 285 1
-
A. Methner, G. Hermey, B. Schinke, I. Hermans-Borgmeyer (1997)
A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development.Biochemical and biophysical research communications, 233 2
-
T. Lawrence, D. Willoughby, D. Gilroy (2002)
Anti-inflammatory lipid mediators and insights into the resolution of inflammationNature Reviews Immunology, 2
-
S. Endres, R. Ghorbani, V. Kelley, K. Georgilis, G. Lonnemann, J. Meer, J. Cannon, T. Rogers, M. Klempner, P. Weber (1989)
The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells.The New England journal of medicine, 320 5
-
J. Topper, Jiexing Cai, D. Falb, M. Gimbrone (1996)
Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress.Proceedings of the National Academy of Sciences of the United States of America, 93 19
-
(1993)
N-3 Fatty Acids and Vascular Disease -
B. McMahon, S. Mitchell, H. Brady, C. Godson (2001)
Lipoxins: revelations on resolution.Trends in pharmacological sciences, 22 8
-
C. Nathan (2002)
Points of control in inflammationNature, 420
-
C. Serhan (2002)
Endogenous Chemical Mediators in Anti-Inflammation and Pro-ResolutionCurrent Medicinal Chemistry - Anti-inflammatory & Anti-allergy Agents, 1
-
T. Yokomizo, T. Izumi, Kyungho Chang, Y. Takuwa, Takao Shimizu (1997)
A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxisNature, 387
-
C. Albert, H. Campos, M. Stampfer, P. Ridker, J. Manson, W. Willett, Jing Ma (2002)
Blood levels of long-chain n-3 fatty acids and the risk of sudden death.The New England journal of medicine, 346 15
-
C. Funk (2001)
Prostaglandins and leukotrienes: advances in eicosanoid biology.Science, 294 5548
-
A. Rowley, D. Hill, Clare Ray, R. Munro (1997)
Haemostasis in Fish – An Evolutionary PerspectiveThrombosis and Haemostasis, 77
-
J. Capdevila, S. Wei, C. Helvig, J. Falck, Y. Belosludtsev, G. Truan, S. Graham-Lorence, J. Peterson (1996)
The Highly Stereoselective Oxidation of Polyunsaturated Fatty Acids by Cytochrome P450BM-3*The Journal of Biological Chemistry, 271
-
C. Serhan, C. Clish, Jessica Brannon, S. Colgan, Chia Nan, K. Gronert (2000)
Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular ProcessingThe Journal of Experimental Medicine, 192
-
Gissi-Prevenzione Investigators (1999)
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trialThe Lancet, 354
- Publisher
- Pubmed Central
- Copyright
- Copyright © 2005, The Rockefeller University Press
- ISSN
- 0022-1007
- eISSN
- 1540-9538
- DOI
- 10.1084/jem.20042031
- Publisher site
- See Article on Publisher Site
Abstract
The essential fatty acid eicosapentaenoic acid (EPA) present in fish oils displays beneficial effects in a range of human disorders associated with inflammation including cardiovascular disease. Resolvin E1 (RvE1), a new bioactive oxygenated product of EPA, was identified in human plasma and prepared by total organic synthesis. Results of bioaction and physical matching studies indicate that the complete structure of RvE1 is 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA. At nanomolar levels, RvE1 dramatically reduced dermal inflammation, peritonitis, dendritic cell (DC) migration, and interleukin (IL) 12 production. We screened receptors and identified one, denoted earlier as ChemR23, that mediates RvE1 signal to attenuate nuclear factor–κB. Specific binding of RvE1 to this receptor was confirmed using synthetic [3H]-labeled RvE1. Treatment of DCs with small interference RNA specific for ChemR23 sharply reduced RvE1 regulation of IL-12. These results demonstrate novel counterregulatory responses in inflammation initiated via RvE1 receptor activation that provide the first evidence for EPA-derived potent endogenous agonists of antiinflammation.
Journal
The Journal of Experimental Medicine – Pubmed Central
Published: Mar 7, 2005