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A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12

A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12 TH E AMERICAN JOURNAL OF HYGIENE VOL. 27 MAY, 1938 No. 3 A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT l 2 ENDPOINTS ' B Y L. J. REED AND H. MUENCH (Received for publication October 26th, 1937) An endpoint in biological procedures such as titration of sera or viruses is usually taken as the dilution at which a certain proportion of test animals react or die. The advantages of using the dilution by which half the animals are affected have been set forth by Gaddum (1) on the basis of pharmacological tests. This endpoint is less affected by small chance variations than is any other; the worst in this respect being the 100 per cent point so frequently used. The best method of determining the endpoint is the use of large numbers of animals at dilutions near the value for 50 per cent reaction, and the interpolation of the correct value by the procedures described by Gaddum. But this is scarcely practical in a great deal of immuno- logical work, where the titer may vary between wide limits in any given test; while highly refined statistical procedures are hardly justified in view of the uncontrolled variables involved. To http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Epidemiology Oxford University Press

A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12

REED, L.J.; MUENCH, H.
American Journal of Epidemiology , Volume 27 (3) – May 1, 1938
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Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
ISSN
0002-9262
eISSN
1476-6256
DOI
10.1093/oxfordjournals.aje.a118408
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Abstract

TH E AMERICAN JOURNAL OF HYGIENE VOL. 27 MAY, 1938 No. 3 A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT l 2 ENDPOINTS ' B Y L. J. REED AND H. MUENCH (Received for publication October 26th, 1937) An endpoint in biological procedures such as titration of sera or viruses is usually taken as the dilution at which a certain proportion of test animals react or die. The advantages of using the dilution by which half the animals are affected have been set forth by Gaddum (1) on the basis of pharmacological tests. This endpoint is less affected by small chance variations than is any other; the worst in this respect being the 100 per cent point so frequently used. The best method of determining the endpoint is the use of large numbers of animals at dilutions near the value for 50 per cent reaction, and the interpolation of the correct value by the procedures described by Gaddum. But this is scarcely practical in a great deal of immuno- logical work, where the titer may vary between wide limits in any given test; while highly refined statistical procedures are hardly justified in view of the uncontrolled variables involved. To

Journal

American Journal of Epidemiology – Oxford University Press

Published: May 1, 1938

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