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Proteolytic regulatory mechanism of chemerin bioactivity

Proteolytic regulatory mechanism of chemerin bioactivity AbstractChemerin is a novel chemoattractant recognized by chemokine-like receptor 1 (CMKLR1), a serpentine receptor expressed primarily by plasmacytoid dendritic cells, natural killer cells, and macrophages. Human prochemerin circulates in plasma as an inactive precursor. Its chemotactic activity is expressed upon cleavage of the C-terminal amino acid residues by proteases of the coagulation, fibrinolytic, and inflammatory system. The C-terminal cleavage site of prochemerin is highly conservative, indicating that the proteolytic regulation of chemerin bioactivity is a common mechanism undertaken by different species. In this review, we summarized chemerin–proteases interactions, chemerin receptors, and their importance in normal and pathologic conditions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Biochimica et Biophysica Sinica Oxford University Press

Proteolytic regulatory mechanism of chemerin bioactivity

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References (92)

Publisher
Oxford University Press
Copyright
© The Author 2009. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.
Subject
Review
ISSN
1672-9145
eISSN
1745-7270
DOI
10.1093/abbs/gmp091
Publisher site
See Article on Publisher Site

Abstract

AbstractChemerin is a novel chemoattractant recognized by chemokine-like receptor 1 (CMKLR1), a serpentine receptor expressed primarily by plasmacytoid dendritic cells, natural killer cells, and macrophages. Human prochemerin circulates in plasma as an inactive precursor. Its chemotactic activity is expressed upon cleavage of the C-terminal amino acid residues by proteases of the coagulation, fibrinolytic, and inflammatory system. The C-terminal cleavage site of prochemerin is highly conservative, indicating that the proteolytic regulation of chemerin bioactivity is a common mechanism undertaken by different species. In this review, we summarized chemerin–proteases interactions, chemerin receptors, and their importance in normal and pathologic conditions.

Journal

Acta Biochimica et Biophysica SinicaOxford University Press

Published: Dec 1, 2009

Keywords: chemerin proteolysis chemotactic inflammation

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