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Cutaneous Melanoma of the Head and Neck: A Review of 399 Cases

Cutaneous Melanoma of the Head and Neck: A Review of 399 Cases Abstract • A retrospective search of the Duke University Melanoma Clinic patients identified 399 cases with primary malignant melanoma located in the head and neck region. Ninety-five percent of the deaths in this series were from metastatic melanoma. Various clinical and pathological data were examined and their effects on survivability and disease-free intervals were evaluated. The characteristics noted included sex, age, depth of the invasion, thickness, site of the lesion, histologic type, and nodal status. A multivariate regression analysis identified the following factors as having a negative effect on survival: nodular histologic type, scalp primary, increasing Clark level, and male sex. In comparing head and neck, extremity, and truncal primary sites, the median survival for patients with head and neck malignant melanomas was notably less. These differences correlated with a higher incidence for male patients, for patients with thicker lesions, and for patients with an increased frequency of nodular histologic type. (Arch Otolaryngol 1983;109:803-808) References 1. Carswell R, cited by Urtega OB, Pack GT: On the antiquity of melanoma . Cancer 1966; 19:607-610.Crossref 2. Pemberton O: Clinical Illustrations of Various Forms of Cancer . London, Longmans, Green, Reader, and Dyer, 1867. 3. Petersen NC, Brodenham DC, Lloyd OC: Malignant melanoma of the skin . Br J Plast Surg 1962;15:49-96.Crossref 4. Ballantyne AJ: Malignant melanoma of the skin of the head and neck . Am J Surg 1970; 120:425-431.Crossref 5. Gupta TK: Results of treatment of 269 patients with primary cutaneous melanoma: A five-year prospective study . Ann Surg 1977; 186:201-209.Crossref 6. Franklin JD, Reynolds WH, Bowers DG, et al: Cutaneous melanoma of the head and neck . Clin Plast Surg 1976;3:413-427. 7. Roses DF, Harris MN, Grunberger I, et al: Selective surgical management of cutaneous melanoma of the head and neck . Ann Surg 1980; 192:629-632.Crossref 8. Clark WH, From L, Bernadino EA, et al: The histiogenesis and biologic behavior of primary human malignant melanomas of the skin . Cancer Res 1969;29:705-726. 9. Cole TB: Melanoma of the head and neck , in Siegler HF (ed): Clinical Management of Melanomas . The Hague, Martinus Mijhoff Publishers, 1982, pp 267-278. 10. Fisher SR, Cole TB, Seigler HF: Application of posterior neck dissection in treating malignant melanoma of the posterior scalp . Laryngoscope 1983;93:760-765.Crossref 11. Rochlin DB: Posterolateral neck dissection for malignant neoplasms . Surg Gynecol Obstet 1962;115:369-373. 12. Wander SU, Chaukhuri PK: Dissection of the posterior part of the neck . Surg Gynecol Obstet 1976;143:97-100. 13. Sullivan DC, Crocker BP, Harris CC, et al: Lymphoscintography in malignant melanoma, Tc-99 antimony sulfur colloid . Am J Radiol 1981;127:847-851. 14. Siegler HF, Fetter BF: Current management of melanoma . Ann Surg 1977;186:1-12.Crossref 15. Ames FC, Sugarbaker EV, Ballantyne AS: Analysis of survival and disease control in stage I melanoma of the head and neck . Am J Surg 1976;132:484-491.Crossref 16. Knutson CD, Hori JM, Watson FR: Melanoma of the head and neck . Am J Surg 1981; 124:470-473. 17. Breslow A: Tumor thickness, level of invasion and node dissection in stage I cutaneous melanoma . Am J Surg 1975;182:572-575. 18. Byers RM, Smith LJ, Russell N, et al: Malignant melanoma of the external ear . Am J Surg 1980;140:518-521.Crossref 19. Olson MO, Woods SE, Soule EH: Regional lymph node management and outcome in 100 patients with head and neck melanoma . Am J Surg 1981;142:470-473.Crossref 20. Storm KF, Eilber FR, Morton DL, et al: Malignant melanoma of the head and neck . Head Neck Surg 1978;1:123-128.Crossref 21. Conrad F: Treatment of malignant melanoma . Arch Surg 1972;104:587-593.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Cutaneous Melanoma of the Head and Neck: A Review of 399 Cases

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References (31)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1983.00800260025006
Publisher site
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Abstract

Abstract • A retrospective search of the Duke University Melanoma Clinic patients identified 399 cases with primary malignant melanoma located in the head and neck region. Ninety-five percent of the deaths in this series were from metastatic melanoma. Various clinical and pathological data were examined and their effects on survivability and disease-free intervals were evaluated. The characteristics noted included sex, age, depth of the invasion, thickness, site of the lesion, histologic type, and nodal status. A multivariate regression analysis identified the following factors as having a negative effect on survival: nodular histologic type, scalp primary, increasing Clark level, and male sex. In comparing head and neck, extremity, and truncal primary sites, the median survival for patients with head and neck malignant melanomas was notably less. These differences correlated with a higher incidence for male patients, for patients with thicker lesions, and for patients with an increased frequency of nodular histologic type. (Arch Otolaryngol 1983;109:803-808) References 1. Carswell R, cited by Urtega OB, Pack GT: On the antiquity of melanoma . Cancer 1966; 19:607-610.Crossref 2. Pemberton O: Clinical Illustrations of Various Forms of Cancer . London, Longmans, Green, Reader, and Dyer, 1867. 3. Petersen NC, Brodenham DC, Lloyd OC: Malignant melanoma of the skin . Br J Plast Surg 1962;15:49-96.Crossref 4. Ballantyne AJ: Malignant melanoma of the skin of the head and neck . Am J Surg 1970; 120:425-431.Crossref 5. Gupta TK: Results of treatment of 269 patients with primary cutaneous melanoma: A five-year prospective study . Ann Surg 1977; 186:201-209.Crossref 6. Franklin JD, Reynolds WH, Bowers DG, et al: Cutaneous melanoma of the head and neck . Clin Plast Surg 1976;3:413-427. 7. Roses DF, Harris MN, Grunberger I, et al: Selective surgical management of cutaneous melanoma of the head and neck . Ann Surg 1980; 192:629-632.Crossref 8. Clark WH, From L, Bernadino EA, et al: The histiogenesis and biologic behavior of primary human malignant melanomas of the skin . Cancer Res 1969;29:705-726. 9. Cole TB: Melanoma of the head and neck , in Siegler HF (ed): Clinical Management of Melanomas . The Hague, Martinus Mijhoff Publishers, 1982, pp 267-278. 10. Fisher SR, Cole TB, Seigler HF: Application of posterior neck dissection in treating malignant melanoma of the posterior scalp . Laryngoscope 1983;93:760-765.Crossref 11. Rochlin DB: Posterolateral neck dissection for malignant neoplasms . Surg Gynecol Obstet 1962;115:369-373. 12. Wander SU, Chaukhuri PK: Dissection of the posterior part of the neck . Surg Gynecol Obstet 1976;143:97-100. 13. Sullivan DC, Crocker BP, Harris CC, et al: Lymphoscintography in malignant melanoma, Tc-99 antimony sulfur colloid . Am J Radiol 1981;127:847-851. 14. Siegler HF, Fetter BF: Current management of melanoma . Ann Surg 1977;186:1-12.Crossref 15. Ames FC, Sugarbaker EV, Ballantyne AS: Analysis of survival and disease control in stage I melanoma of the head and neck . Am J Surg 1976;132:484-491.Crossref 16. Knutson CD, Hori JM, Watson FR: Melanoma of the head and neck . Am J Surg 1981; 124:470-473. 17. Breslow A: Tumor thickness, level of invasion and node dissection in stage I cutaneous melanoma . Am J Surg 1975;182:572-575. 18. Byers RM, Smith LJ, Russell N, et al: Malignant melanoma of the external ear . Am J Surg 1980;140:518-521.Crossref 19. Olson MO, Woods SE, Soule EH: Regional lymph node management and outcome in 100 patients with head and neck melanoma . Am J Surg 1981;142:470-473.Crossref 20. Storm KF, Eilber FR, Morton DL, et al: Malignant melanoma of the head and neck . Head Neck Surg 1978;1:123-128.Crossref 21. Conrad F: Treatment of malignant melanoma . Arch Surg 1972;104:587-593.Crossref

Journal

Archives of Otolaryngology – American Medical Association

Published: Dec 1, 1983

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