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- Publisher
- Karger
- Copyright
- © 1999 S. Karger AG, Basel
- ISSN
- 0378-5866
- eISSN
- 1421-9859
- DOI
- 10.1159/000017380
- Publisher site
- See Article on Publisher Site
Abstract
The effects of modulators of GABA-A receptors on neuronal network activity were studied in the neonatal (postnatal days 0–5) rat hippocampus in vitro. Under control conditions, the physiological pattern of activity of the neonatal hippocampal network was characterized by spontaneous network-driven giant depolarizing potentials (GDPs). The GABA-A receptor agonist isoguvacine (1–2 μM) and the allosteric modulator diazepam (2 μM) induced biphasic responses: initially the frequency of GDPs increased 3 to 4 fold followed by blockade of GDPs and desynchronization of the network activity. The GABA-A receptor antagonists bicuculline (10 μM) and picrotoxin (100 μM) blocked GDPs and induced glutamate (AMPA and NMDA)-receptor-mediated interictal- and ictal-like activities in the hippocampal slices and the intact hippocampus. These data suggest that at early postnatal ages GABA can exert a dual – both excitatory and inhibitory – action on the network activity.
Journal
Developmental Neuroscience – Karger
Published: Nov 1, 1999
Keywords: Bicuculline; Diazepam; γ-Aminobutyric acid; Development; Hippocampus; Seizure