Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

The Shwartzman reaction: a review including clinical manifestations and proposal for a univisceral or single organ third type

The Shwartzman reaction: a review including clinical manifestations and proposal for a... The Shwartzman reaction was first described more than 50 years ago and two types, the generalized and the localized, were established in the early 1930s. Studies were mostly related to experimental pathology or immunology, and its significance in clinical medicine was initially obscure though thought to be obstetrically relevant. It is thought that the generalized type has a relation to human disease and that disseminated intravascular coagulation in man is really the counterpart of the generalized Shwartzman reaction in animals. The localized type on the other hand does not have obvious practical clinical pathological significance and tumour necrosis may be the only real example which is commonly seen. Further studies on the Shwartzman reaction relevant to human pathology have, however, suggested that it could be applied to several diseases, the pathogenesis of which was still obscure. The significance seems, however, different from either the generalized or localized type of reaction and so a proposal of the incidence of a third type—‘univisceral’ or ‘single organ’ Shwartzman reaction is made. Acute liver necrosis, Waterhouse‐Friderichsen's syndrome, haemolytic uraemic anaemia, idiopathic pulmonary haemorrhage, acute pancreatitis, acute pituitary necrosis and pseudomembranous colitis all seem to have features suggesting that they could be clinical manifestations of this type of Shwartzman reaction with focal intravascular coagulation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Histopathology Wiley

The Shwartzman reaction: a review including clinical manifestations and proposal for a univisceral or single organ third type

MORI, W.
Histopathology , Volume 5 (2) – Mar 1, 1981
Download PDF
14 pages

Loading next page...
 
/lp/wiley/the-shwartzman-reaction-a-review-including-clinical-manifestations-and-Gubd8AEwKU

References (79)

Publisher
Wiley
Copyright
Copyright © 1981 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0309-0167
eISSN
1365-2559
DOI
10.1111/j.1365-2559.1981.tb01772.x
Publisher site
See Article on Publisher Site

Abstract

The Shwartzman reaction was first described more than 50 years ago and two types, the generalized and the localized, were established in the early 1930s. Studies were mostly related to experimental pathology or immunology, and its significance in clinical medicine was initially obscure though thought to be obstetrically relevant. It is thought that the generalized type has a relation to human disease and that disseminated intravascular coagulation in man is really the counterpart of the generalized Shwartzman reaction in animals. The localized type on the other hand does not have obvious practical clinical pathological significance and tumour necrosis may be the only real example which is commonly seen. Further studies on the Shwartzman reaction relevant to human pathology have, however, suggested that it could be applied to several diseases, the pathogenesis of which was still obscure. The significance seems, however, different from either the generalized or localized type of reaction and so a proposal of the incidence of a third type—‘univisceral’ or ‘single organ’ Shwartzman reaction is made. Acute liver necrosis, Waterhouse‐Friderichsen's syndrome, haemolytic uraemic anaemia, idiopathic pulmonary haemorrhage, acute pancreatitis, acute pituitary necrosis and pseudomembranous colitis all seem to have features suggesting that they could be clinical manifestations of this type of Shwartzman reaction with focal intravascular coagulation.

Journal

Histopathology – Wiley

Published: Mar 1, 1981

There are no references for this article.